Interaction between two cylindrical inclusions in a symmetric lipid bilayer
Interaction between two cylindrical inclusions in a symmetric lipid bilayer
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DOI：
10.1063/1.1607305
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发表时间：
2003-10-08
影响因子：
4.4
通讯作者：
May, S
中科院分区：
文献类型：
--
作者：
Bohinc, K;Kralj-Iglic, V;May, S
我们计算了对称脂质双层中两个圆柱形内含物之间的膜介导的相互作用。我们的理论考虑到自由能的两个贡献，膜的弹性行为和脂质的柔性烃链在刚性内含物附近经历的构象限制。的弹性行为的描述是基于两个顺序参数，膜的疏水厚度和指向矢场，其特征在于的脂质链的平均倾斜。通过简单的指向矢模型考虑了脂链的构象限制。我们发现，两个夹杂物之间的短程相互作用势敏感地依赖于疏水失配的程度和脂质层的自发曲率。特别是，我们发现明显的吸引力，如果疏水性错配是积极的。对于负失配的吸引力是不太明显，此外，一个充满活力的障碍出现。夹杂物更倾向于一个小的，但值得注意的负疏水性错配。正的自发曲率放大了这些行为。(C)2003年，美国物理学会。
We calculate the membrane-mediated interaction between two cylindrical inclusions in a symmetric lipid bilayer. Our theory takes two contributions to the free energy into account, the elastic behavior of the membrane and the conformational restrictions that the flexible hydrocarbon chains of the lipids experience in the vicinity of a rigid inclusion. The description of the elastic behavior is based on two order parameters, the hydrophobic thickness of the membrane and a director field that characterizes the average tilt of the lipid chains. Conformational restrictions of the lipid chains are taken into account by a simple director model. We show that the short-range interaction potential between two inclusions sensitively depends on the degree of hydrophobic mismatch and on the spontaneous curvature of the lipid layers. In particular, we find pronounced attraction if the hydrophobic mismatch is positive. For negative mismatch the attraction is much less pronounced and, additionally, an energetic barrier appears. The inclusions prefer a small but notable negative hydrophobic mismatch. Positive spontaneous curvature amplifies these behaviors. (C) 2003 American Institute of Physics.