Hepatic-portal oleic acid inhibits feeding more potently than hepatic-portal caprylic acid in rats
Hepatic-portal oleic acid inhibits feeding more potently than hepatic-portal caprylic acid in rats
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DOI：
10.1016/j.physbeh.2006.06.020
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发表时间：
2006-10-30
影响因子：
2.9
通讯作者：
Leonhardt, Monika
中科院分区：
文献类型：
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作者：
Jambor de Sousa, Ulrike L.;Benthem, Lambertus;Leonhardt, Monika
在几项人类和动物研究中，中链甘油三酯比长链甘油三酯更能减少食物摄入量。可能是肝脏中中链脂肪酸的更快吸收和代谢导致了这种差异。为了验证这一假设，我们比较了肝门静脉（HPV）输注中链脂肪酸辛酸（CA）与长链脂肪酸油酸（OA）的喂养效果。与我们的预期相反，6小时HPV输注14 μ g/min（50 nmol/min）OA强烈抑制摄食，而输注22或220 μ g/min（150和1500 nmol/min）CA对摄食没有任何影响。只有更大剂量的CA（1100 μ g/min（7500 nmol/ min））才能抑制进食，与14 μ g/min的OA类似。OA的摄食抑制效力增加似乎不是由于肝脂肪酸氧化刺激的差异，因为等摩尔（50 nmol/min）剂量的OA（14 μ g/min）和CA（7 μ g/min）对输注后β-羟基丁酸盐水平的影响没有差异。应激、炎症、急性肝毒性或氧化应激似乎也不能解释HPV OA的摄食抑制效力增加，因为应激激素皮质酮和肾上腺素、促炎细胞因子白细胞介素-6和肿瘤坏死因子-α的血浆浓度，肝酶γ-谷氨酰转移酶和丙氨酸氨基转移酶以及肝脏丙二醛和谷胱甘肽水平在HPV输注生理盐水或50 nmol/min OA或CA。(c)2006年爱思唯尔公司All rights reserved.
In several human and animal studies, medium-chain triglycerides decreased food intake more than did long-chain triglycerides. It is possible that faster uptake and metabolism of medium-chain fatty acids in the liver is responsible for this difference. To test this hypothesis we compared the feeding effects of hepatic portal vein (HPV) infusion of the medium-chain fatty acid caprylic acid (CA) with those of the long-chain fatty acid oleic acid (OA). Contrary to our expectation, six-h HPV infusion of 14 mu g/min (50 nmol/min) OA robustly inhibited feeding, whereas infusion of 22 or 220 mu g/min (150 and 1500 nmol/min) CA failed to have any effect on feeding. Only a much larger dose of CA, 1100 mu g/min (7500 nmol/ min) inhibited feeding similarly to 14 mu g/min OA. The increased feeding-inhibitory potency of OA did not appear to be due to differences in stimulation of hepatic fatty acid oxidation because equimolar (50 nmol/min) doses of OA (14 mu g/min) and CA (7 mu g/min) did not differentially affect post-infusion levels of beta-hydroxybutyrate. Stress, inflammation, acute hepatotoxicity or oxidative stress also do not appear to account for the increased feeding-inhibitory potency of HPV OA because plasma concentrations of the stress hormones corticosterone and epinephrine, the pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-alpha, the liver enzymes gamma-glutamyl transferase and alanine aminotransferase and as well as hepatic levels of malondialdehyde and glutathione were all similar after HPV infusion of saline or of 50 nmol/min OA or CA. (c) 2006 Elsevier Inc. All rights reserved.