Quality of Life and Self-Reported Lower Extremity Function in Adults With HIV-Related Distal Sensory Polyneuropathy
Quality of Life and Self-Reported Lower Extremity Function in Adults With HIV-Related Distal Sensory Polyneuropathy
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DOI：
10.2522/ptj.20130337
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发表时间：
2014-10-01
期刊：
影响因子：
3.2
通讯作者：
Condoluci, David V.
中科院分区：
文献类型：
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作者：
Galantino, Mary Lou A.;Kietrys, David M.;Condoluci, David V.
背景。远端感觉多神经病变（DSP）是HIV疾病的常见并发症。其对生活质量（QOL）和功能的影响尚未得到很好的描述。研究目的是：(1)比较HIV相关DSP患者和无DSP的HIV患者的生活质量和下肢功能，(2)确定功能预测生活质量的程度，(3)评估2个功能量表的一致性，(4)描述疼痛管理资源的使用。本研究为横断面调查研究，采用预测模型和测量工具，一致性验证。使用了人口统计问卷、医学结果研究HIV健康调查、下肢功能量表（LEFS）、下肢功能指数（LLFI）和对医疗记录的回顾。采用一般线性模型评估各组生活质量差异及功能与生活质量的关系。使用Bland-Altman程序来评估LEES和llfi的一致性。可用于分析的数据来自82或94名参与者。报告有DSP症状的67%的参与者往往年龄较大，感染HIV的时间较长，并且更有可能获得残疾福利。无DSP的参与者LLFI、LEFS和身体健康总结得分更好。在多变量模型中，下肢功能预测身体和心理健康总结得分。与LEFS相比，LLFI更常识别出功能水平较低的参与者。患有DSP的参与者更有可能使用药物治疗、物理治疗以及补充或替代治疗。使用了方便样本；样本量导致医疗结果研究HIV健康调查的心理健康总结得分的功率较低。HIV疾病和DSP患者的生活质量和功能受损更严重。LLFI比LEFS更有可能捕捉到功能上的限制。患有DSP的参与者报告更频繁地使用疼痛管理资源。
Background. Distal sensory polyneuropathy (DSP) is a common complication of HIV disease. Its effects on quality of life (QOL) and function have not been well described.Objective. The study objectives were: (1) to compare QOL and lower extremity function in people with HIV-related DSP and people with HIV disease who do not have DSP, (2) to determine the extent to which function predicts QOL, (3) to evaluate the agreement of 2 function scales, and (4) to describe the use of pain management resources.Design. This was a cross-sectional survey study with predictive modeling an measurement tool concordant validation.Methods. A demographic questionnaire, the Medical Outcomes Study HIV Health Survey, the Lower Extremity Functional Scale (LEFS), the Lower Limb Functional Index (LLFI), and a review of medical records were used. General linear modeling was used to assess group differences in QOL and the relationship between function and QOL. Bland-Altman procedures were used to assess the agreement of the LEES and the LLFI.Results. Usable data for analyses were available for 82 or the 94 participants enrolled. The 67% of participants who reported DSP symptoms tended to be older, had HIV disease longer, and were more likely to receive disability benefits. Participants without DSP had better LLFI, LEFS, and physical health summary scores. In multivariate models, lower limb function predicted physical and mental health summary scores. The LLFI identified participants with a lower level of function more often than the LEFS. Participants with DSP were more likely to use medical treatment, physical therapy, and complementary or alternative treatments.Limitations. A sample of convenience was used; the sample size resulted in a low power for the mental health summary score of the Medical Outcomes Study HIV Health Survey.Conclusions. Quality of life and function were more impaired in participants with HIV disease and DSP. The LLFI was more likely to capture limitations in function than the LEFS. Participants with DSP reported more frequent use of pain management resources.