Information flow, cell types and stereotypy in a full olfactory connectome.
Information flow, cell types and stereotypy in a full olfactory connectome.
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DOI：
10.7554/elife.66018
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发表时间：
2021-05-25
期刊：
影响因子：
7.7
通讯作者：
Jefferis GSXE
中科院分区：
文献类型：
--
作者：
Schlegel P;Bates AS;Stürner T;Jagannathan SR;Drummond N;Hsu J;Serratosa Capdevila L;Javier A;Marin EC;Barth-Maron A;Tamimi IF;Li F;Rubin GM;Plaza SM;Costa M;Jefferis GSXE
半脑连接体为果蝇的大部分中央脑提供了大规模的连接和形态学信息。使用这个数据集，我们提供了一个完整的描述果蝇嗅觉系统，涵盖所有的第一，第二和侧角相关的三级神经元。我们开发了一种普遍适用的策略，从连接图中提取信息流和分层组织，将嗅觉输入映射到下行中间神经元。这确定了一系列的图案，包括高度偏侧电路的触角叶和模式的收敛下游的蘑菇体和侧角。利用第二个数据集，我们提供了一个第一个定量评估之间与个体内的刻板印象。比较两个大脑（三个半球）的神经元显示出大脑神经元形态的惊人相似性。连接性与形态学相关，相同形态学类型的神经元在同一大脑内显示出与两个大脑之间相似的连接变异性。
The hemibrain connectome provides large-scale connectivity and morphology information for the majority of the central brain of Drosophila melanogaster. Using this data set, we provide a complete description of the Drosophila olfactory system, covering all first, second and lateral horn-associated third-order neurons. We develop a generally applicable strategy to extract information flow and layered organisation from connectome graphs, mapping olfactory input to descending interneurons. This identifies a range of motifs including highly lateralised circuits in the antennal lobe and patterns of convergence downstream of the mushroom body and lateral horn. Leveraging a second data set we provide a first quantitative assessment of inter- versus intra-individual stereotypy. Comparing neurons across two brains (three hemispheres) reveals striking similarity in neuronal morphology across brains. Connectivity correlates with morphology and neurons of the same morphological type show similar connection variability within the same brain as across two brains.