An All-Organic Semiconductor C3N4/PDINH Heterostructure with Advanced Antibacterial Photocatalytic Therapy Activity
An All-Organic Semiconductor C3N4/PDINH Heterostructure with Advanced Antibacterial Photocatalytic Therapy Activity
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DOI：
10.1002/adma.201901965
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发表时间：
2019-08-01
影响因子：
29.4
通讯作者：
Chen, Chunying
中科院分区：
文献类型：
--
作者：
Wang, Longwei;Zhang, Xiao;Chen, Chunying
抗菌光催化疗法已被报道为一种有前途的替代水消毒技术，用于对抗耐药性细菌。已经开发了许多无机纳米系统作为细菌感染治疗的抗生素替代品，但由于重金属物质的毒性风险，这些都是有限的。有机半导体光催化材料因其良好的生物相容性、化学可调的电子结构、多样的结构柔性、合适的带隙、低廉的成本以及所需资源的丰富而引起人们的极大关注。通过在C3 N4表面原位重结晶3，4，9，10-四羧酸二酰亚胺（PDINH），制备了一种全有机复合光催化纳米材料C3 N4/PDINH异质结构。这种复合结构的吸收光谱可以从紫外光扩展到近红外光（750 nm），增强了光催化作用，产生更多的活性氧，对革兰氏阴性菌和阳性菌都有很好的灭活效果，同时对正常组织细胞的毒性可以忽略不计。证明了在具有金黄色葡萄球菌感染的皮肤伤口的小鼠中有效促进感染性伤口再生。这种全有机异质结构在伤口消毒中显示出巨大的前景。
Antibacterial photocatalytic therapy has been reported as a promising alternative water disinfection technology for combating antibiotic-resistant bacteria. Numerous inorganic nanosystems have been developed as antibiotic replacements for bacterial infection treatment, but these are limited due to the toxicity risk of heavy metal species. Organic semiconductor photocatalytic materials have attracted great attention due to their good biocompatibility, chemically tunable electronic structure, diverse structural flexibility, suitable band gap, low cost, and the abundance of the resources they require. An all-organic composite photocatalytic nanomaterial C3N4/perylene-3,4,9,10-tetracarboxylic diimide (PDINH) heterostructure is created through recrystallization of PDINH on the surface of C3N4 in situ, resulting in enhanced photocatalytic efficiency due to the formation of a basal heterostructure. The absorption spectrum of this composite structure can be extended from ultraviolet to near-infrared light (750 nm), enhancing the photocatalytic effect to produce more reactive oxygen species, which have an excellent inactivation effect on both Gram-negative and positive bacteria, while demonstrating negligible toxicity to normal tissue cells. An efficient promotion of infectious wound regeneration in mice with Staphylococcus aureus infected dermal wounds is demonstrated. This all-organic heterostructure shows great promise for use in wound disinfection.