Testosterone-induced nuclear changes in the rat uterine luminal epithelium. A stereological study.
Testosterone-induced nuclear changes in the rat uterine luminal epithelium. A stereological study.
复制标题
睾酮诱导的大鼠子宫腔上皮细胞核变化。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
David
中科院分区：
文献类型：
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作者：
Cidadão Aj;David
对绝育的未成熟雌性大鼠施用睾酮会导致子宫上皮细胞的核超微结构发生显着变化。一般来说，当使用较高剂量时，这些变化会增加。最剧烈的变化发生在核仁：体积密度和体积增加；所有核仁区室的体积增加；颗粒和空泡体积密度增加；纤维中心数量增加，但观察到它们各自的体积减少。浓缩染色质体积密度和体积减少。核体积、核膜表面、核体体积密度和频率几乎保持相同。即使使用小剂量的睾酮（0.5 mg），凝聚和分散染色质、纤维中心和纤维成分以及凝聚染色质和纤维成分之间界面的表面密度也显示出显着变化。这样的剂量无法改变浓缩染色质或纤维中心的体积密度。讨论了我们的结果与生化或其他形态学数据之间的相关性。
Testosterone administration to the spayed immature female rat produces significant changes in the nuclear ultrastructure of the uterine epithelial cells. In general, these changes increase when a higher dose is used. The most intense changes occur in the nucleolus: volume density and volume increase; volume increases in all nucleolar compartments; granular and vacuolar volume density increase; fibrillar center number increase, but a reduction of their individual volume is observed. Condensed chromatin volume density and volume decrease. Nuclear volume, nuclear envelope surface, and nuclear body volume density and frequency remain almost the same. The surface density of the interface between condensed and dispersed chromatin, fibrillar centers and fibrillar component, and condensed chromatin and fibrillar component, show significant variations even with a small dose of testosterone (0.5 mg). Such a dose is unable to change the volume density of condensed chromatin or fibrillar centers. Correlations between our results and biochemical or other morphological data are discussed.