Prevalence of Age-Related Macular Degeneration in the US Population
Prevalence of Age-Related Macular Degeneration in the US Population
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DOI：
10.1001/archophthalmol.2010.318
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发表时间：
2011-01-01
影响因子：
--
通讯作者：
Saaddine, Jinan B.
中科院分区：
文献类型：
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作者：
Klein, Ronald;Chou, Chiu-Fang;Saaddine, Jinan B.
目的：调查非西班牙裔白人、非西班牙裔黑人、墨西哥裔美国人和其他种族/族裔群体中年龄相关性黄斑变性 (AMD) 的患病率。 设计：一项美国全国代表性、基于人口的横断面研究，涉及 2005-2008 年国家健康和营养检查调查中 5553 名 40 岁及以上的人。主要结果指标是通过使用标准化协议对双眼 45 度数字图像进行分级来确定 AMD。 结果：在 40 岁及以上的平民、非机构化美国人口中，任何 AMD 的估计患病率为 6.5%（95% 置信区间，5.5-7.6），晚期 AMD 的估计患病率为 0.8%（95% 置信区间，0.5-1.3）。 60 岁及以上的非西班牙裔黑人的任何 AMD 患病率在统计上显着低于 60 岁及以上的非西班牙裔白人（比值比 = 0.37；95% 置信区间，0.21-0.67）。 结论：总体而言，2005-2008 年全国健康和营养检查调查中任何 AMD 的患病率为 6.5%，低于 9.4% 1988-1994 年第三次全国健康和营养调查报告的患病率。虽然这一发现可能在一定程度上可以用可能的方法学差异来解释，但这些估计与 AMD 发病率的下降是一致的，并表明了重要的公共卫生保健意义。
Objective: To examine the prevalence of age-related macular degeneration (AMD) in non-Hispanic white, non-Hispanic black, Mexican American, and other racial/ethnic groups.Design: A US nationally representative, population-based, cross-sectional study involving a total of 5553 persons aged 40 years and older from the 2005-2008 National Health and Nutrition Examination Survey. The main outcome measure was AMD determined by the grading of 45 degrees digital images from both eyes using a standardized protocol.Results: In the civilian, noninstitutionalized, US population aged 40 years and older, the estimated prevalence of any AMD was 6.5% (95% confidence interval, 5.5-7.6) and the estimated prevalence of late AMD was 0.8% (95% confidence interval, 0.5-1.3). Non-Hispanic black persons aged 60 years and older had a statistically significantly lower prevalence of any AMD than non-Hispanic white persons aged 60 years and older (odds ratio=0.37; 95% confidence interval, 0.21-0.67).Conclusions: Overall, the prevalence of any AMD in the 2005-2008 National Health and Nutrition Examination Survey was 6.5%, which is lower than the 9.4% prevalence reported in the 1988-1994 Third National Health and Nutrition Examination Survey. While this finding might be explained in part by possible methodological differences, these estimates are consistent with a decreasing incidence of AMD and suggest important public health care implications.