The sensory cilia of Caenorhabditis elegans.
The sensory cilia of Caenorhabditis elegans.
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DOI：
10.1895/wormbook.1.126.2
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
P. N. Inglis;Guangshuo Ou;M. Leroux;J. Scholey
中科院分区：
文献类型：
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作者：
P. N. Inglis;Guangshuo Ou;M. Leroux;J. Scholey
曾经被认为是退化细胞结构的非运动纤毛，现在越来越多地与各种细胞和生物体感知其化学和物理环境的能力相关。由于其有限的感觉纤毛和多样的行为剧目，C。线虫已经成为研究纤毛如何形成、功能以及最终调节复杂行为的强大实验系统。本文讨论了该属植物的发生、分布、结构、组成和一般功能。秀丽隐翅虫我们还简要介绍了如何C。线虫正被用于提供对各种人类纤毛病的分子见解，包括多囊性肾病和Bardet-Biedl综合征。
The non-motile cilium, once believed to be a vestigial cellular structure, is now increasingly associated with the ability of a wide variety of cells and organisms to sense their chemical and physical environments. With its limited number of sensory cilia and diverse behavioral repertoire, C. elegans has emerged as a powerful experimental system for studying how cilia are formed, function, and ultimately modulate complex behaviors. Here, we discuss the biogenesis, distribution, structures, composition and general functions of C. elegans cilia. We also briefly highlight how C. elegans is being used to provide molecular insights into various human ciliopathies, including Polycystic Kidney Disease and Bardet-Biedl Syndrome.