Vestibular influences on CA1 neurons in the rat hippocampus: an electrophysiological study in vivo
Vestibular influences on CA1 neurons in the rat hippocampus: an electrophysiological study in vivo
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DOI：
10.1007/s00221-003-1725-9
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发表时间：
2004-03-01
影响因子：
2
通讯作者：
Bilkey, DK
中科院分区：
文献类型：
--
作者：
Horii, A;Russell, NA;Bilkey, DK
已知前庭信息对于准确的空间定向和导航是重要的。海马位置细胞，似乎编码动物在环境中的位置，也被认为在空间定位中发挥重要作用。因此，可以假设，前庭信息可能会影响角氨区1（CA1）海马神经元的活动。为了探讨这种可能性，电刺激前庭内侧核（MVN）对海马CA1区神经元放电频率的影响，在麻醉大鼠用细胞外单单位记录。CA1复合锋细胞（n=29），这最有可能对应于位置细胞，一致的放电率增加，在电流强度依赖的方式在MVN的电刺激。在MVN附近施加刺激未能引起反应。总体而言，非复杂的棘细胞（n=22）的放电率没有显示出一致的反应前庭刺激，虽然在一些细胞中观察到明确的刺激反应。这些发现表明，前庭输入可能有助于空间信息处理的海马。
Vestibular information is known to be important for accurate spatial orientation and navigation. Hippocampal place cells, which appear to encode an animal's location within the environment, are also thought to play an essential role in spatial orientation. Therefore, it can be hypothesized that vestibular information may influence cornu ammonis region 1 (CA1) hippocampal neuronal activity. To explore this possibility, the effects of electrical stimulation of the medial vestibular nucleus (MVN) on the firing rates of hippocampal CA1 neurons in the urethane-anesthetized rat were investigated using extracellular single unit recordings. The firing rates of CA1 complex spike cells (n=29), which most likely correspond to place cells, consistently increased during electrical stimulation of the MVN in a current intensity dependent manner. Stimulation applied adjacent to the MVN failed to elicit a response. Overall, the firing rates of non-complex spike cells (n=22) did not show a consistent response to vestibular stimulation, although in some cells clear responses to the stimulation were observed. These findings suggest that vestibular inputs may contribute to spatial information processing in the hippocampus.