Biological Activities of Aggregated Gamma Globulin I. Skin Reactive and Complement-Fixing Properties of Heat Denatured Gamma Globulin.∗
Biological Activities of Aggregated Gamma Globulin I. Skin Reactive and Complement-Fixing Properties of Heat Denatured Gamma Globulin.∗
复制标题
聚集的丙种球蛋白的生物活性 I. 热变性丙种球蛋白的皮肤反应性和补体固定特性。*
DOI：
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发表时间：
1959
期刊：
影响因子：
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通讯作者：
K. Ishizaka
中科院分区：
文献类型：
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作者：
T. Ishizaka;K. Ishizaka
Summary 1. Aggregated human gamma globulin, obtained by heating, gave immediate skin reactions in normal guinea pigs and inactivated complement, whereas aggregated bovine gamma globulin did not have either activity. 2. Aggregated human gamma globulin and antigen-antibody complexes are comparable on weight basis with respect to skin reactivity and complement inactivation. 3. Divalent cation(s) are required for inactivation of complement by aggregated HGG. Inactivation of C'3 by aggregated HGG is markedly dependent upon temperature. 4. A tentative hypothesis concerning the mechanism of complement fixation by antigen-antibody reaction is presented.
