Utility of controlled attenuation parameter measurement for assessing liver steatosis in Japanese patients with chronic liver diseases
Utility of controlled attenuation parameter measurement for assessing liver steatosis in Japanese patients with chronic liver diseases
复制标题
DOI：
10.1111/hepr.12094
复制
发表时间：
2013-11-01
影响因子：
4.2
通讯作者：
Chayama, Kazuaki
中科院分区：
文献类型：
--
作者：
Masaki, Keiichi;Takaki, Shintaro;Chayama, Kazuaki
目的脂肪变性是慢性肝病，尤其是酒精性和非酒精性脂肪性肝病以及慢性丙型肝炎的共同组织学特征。最近的一项研究表明，用瞬时弹性成像技术评估受控衰减参数(CAP)是无创性判断肝脏脂肪变性严重程度的有效方法。本研究的目的是前瞻性地评价CAP对慢性肝病患者脂肪变性的诊断价值。方法对155例疑似慢性肝病患者进行CAP、血样分析、CT肝/脾比值测定和肝活检。脂肪变性按含脂肪肝细胞百分比进行分级：S0，小于5%；S1，5~33%；S2，34~66%；S3：66%以上。结果脂肪变性患者的CAP与脂肪变性程度显著相关，且S0患者的CAP值与其他程度的脂肪变性患者的CAP值有显著差异。S0和S1-3分别被认为是轻度和严重的脂肪变性。轻度脂肪变性组与重度脂肪变性组的CAP值差异有统计学意义(P
AimSteatosis is a common histological feature of chronic liver disease, especially alcoholic and non-alcoholic fatty liver disease, as well as chronic hepatitis C. A recent study showed that evaluating the controlled attenuation parameter (CAP) with transient elastography was an efficient way of non-invasively determining the severity of hepatic steatosis. The objective of this study was to prospectively evaluate the utility of CAP for diagnosing steatosis in patients with chronic liver disease.MethodsOne hundred and fifty-five consecutive patients with suspected chronic liver disease underwent steatosis diagnosis using CAP, blood sample analyses, computed tomography for assessing the liver/spleen ratio and liver biopsy. Steatosis was graded according to the percentage of fat-containing hepatocytes: S0, less than 5%; S1, 5-33%; S2, 34-66%; and S3: more than 66%.ResultsThe CAP was significantly correlated with steatosis grade, and there were significant differences between the CAP value of the S0 patients and those of the patients with other grades of steatosis. S0 and S1-3 hepatic steatosis were considered to represent mild and significant steatosis, respectively. The CAP values of the patients with mild and significant steatosis were significantly different (P