Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis
Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis
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DOI：
10.1126/science.281.5377.703
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发表时间：
1998-07-31
期刊：
影响因子：
56.9
通讯作者：
Huber, BT
中科院分区：
文献类型：
--
作者：
Gross, DM;Forsthuber, T;Huber, BT
难治性莱姆关节炎与伯氏疏螺旋体（莱姆病的病原体）外表面蛋白 A (OspA) 的免疫反应性以及主要组织相容性复合体 II 类等位基因 DRB1*0401 相关。鉴定了 T 辅助细胞的 OspA 免疫显性表位。同源性搜索揭示了来自人白细胞功能相关抗原 1 (hLFA-1) 的肽作为候选自身抗原。患有难治性莱姆关节炎（而非其他形式的关节炎）的个体会对 OspA、hLFA-1 及其高度相关的肽表位产生反应。起始细菌抗原和交叉反应性自身抗原的鉴定可以为自身免疫性疾病的发展提供模型。
Treatment-resistant Lyme arthritis is associated with immune reactivity to outer surface protein A (OspA) of Borrelia burgdorferi, the agent of Lyme disease, and the major histocompatibility complex class II allele DRB1*0401. The immunodominant epitope of OspA for T helper cells was identified. A homology search revealed a peptide from human leukocyte function-associated antigen-1 (hLFA-1) as a candidate autoantigen. Individuals with treatment-resistant Lyme arthritis, but not other forms of arthritis, generated responses to OspA, hLFA-1, and their highly related peptide epitopes. Identification of the initiating bacterial antigen and a cross-reactive autoantigen may provide a model for development of autoimmune disease.