Treatment of Glioma in the 21 st Century: An Exciting Decade of Postsurgical Treatment Advances in the Molecular Era
Treatment of Glioma in the 21 st Century: An Exciting Decade of Postsurgical Treatment Advances in the Molecular Era
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DOI：
10.1016/j.mayocp.2017.01.010
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发表时间：
2017-06-01
影响因子：
8.9
通讯作者：
Porter, Alyx B.
中科院分区：
文献类型：
--
作者：
Uhm, Joon H.;Porter, Alyx B.
过去十年我们的分类方式发生了重大变化，并开始接触高级别神经胶质瘤患者。随着我们走向个性化医疗，我们现在能够利用每个人肿瘤的分子特征来定制治疗方案，特别是当患者年龄较大或基线时体能状态较差时。我们讨论截至 2016 年化疗、免疫治疗和肿瘤治疗领域的实践状况。这篇综述的目的是增强读者对细微差别的理解，使临床医生能够更具体地制定高级别胶质瘤的治疗方案。 (C) 2017 年梅奥医学教育和研究基金会。
The past decade has brought about major changes in the way we classify and have begun to approach patients with high-grade glioma. As we trend toward personalized medicine, we are now able to utilize the molecular characteristics of each individual's tumor in order to tailor their treatment, particularly if the patient is elderly or has a poor performance status at baseline. We address the state of the practice as of 2016 in regard to chemotherapy, immunotherapy, and tumor-treating fields. The goal of this review is to enhance readers' understanding of the nuances that are allowing clinicians to tailor the treatment of high-grade glioma more specifically. (C) 2017 Mayo Foundation for Medical Education and Research.