Resting-State Alpha in Autism Spectrum Disorder and Alpha Associations with Thalamic Volume
Resting-State Alpha in Autism Spectrum Disorder and Alpha Associations with Thalamic Volume
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DOI：
10.1007/s10803-014-2236-1
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发表时间：
2015-03-01
影响因子：
3.9
通讯作者：
Roberts, Timothy P. L.
中科院分区：
文献类型：
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作者：
Edgar, J. Christopher;Heiken, Kory;Roberts, Timothy P. L.
阿尔法回路（8-12 Hz）对于基本和复杂的大脑过程是必需的，但在自闭症谱系障碍（ASD）中却是异常的。本研究获得了 ASD 儿童静息态 (RS) α 活性的估计值，并检查了 α 活性、年龄和临床症状之间的关联。鉴于丘脑调节皮质 RS α 节律，因此检查了丘脑结构和 α 活动之间的关联。 RS 脑磁图是从 47 名正常发育儿童 (TDC) 和 41 名患有自闭症谱系障碍 (ASD) 的儿童中获得的。 RS α 活动是使用分布式源定位来测量的。还获得了左侧和右侧丘脑体积测量值。在两组中，在距状沟区域观察到最强的α活性。在 Calcarine 地区，只有 TDC 显示了年龄和 α 峰值频率之间的预期关联。在与中央沟和顶叶联合皮层接壤的区域，自闭症谱系障碍 (ASD) 的 α 活性高于 TDC。在 ASD 中，左中央沟相对 α 活动越大，社会反应量表 (SRS) 得分越高，距状区相对 α 活动越大，SRS 得分越低。尽管没有观察到丘脑体积组差异，但丘脑体积和 Calcarine α 功率之间的关系是 TDC 所独有的。本研究还发现，自闭症谱系障碍 (ASD) 儿童的主要 α 生成区域的峰值 α 频率未能随年龄变化而变化。研究结果表明，初级运动和体感以及顶叶多模态区域的 RS α 活性增加（α 增加被认为反映了更大的抑制）可能会损害识别或解释社交线索的能力。最后，据我们所知，这是第一项报告丘脑体积与 α 功率之间关联的研究，这种关联仅在 TDC 中观察到。 ASD 中丘脑和 α 关联的缺乏表明丘脑对 ASD 中 RS α 异常有贡献。
Alpha circuits (8-12 Hz), necessary for basic and complex brain processes, are abnormal in autism spectrum disorder (ASD). The present study obtained estimates of resting-state (RS) alpha activity in children with ASD and examined associations between alpha activity, age, and clinical symptoms. Given that the thalamus modulates cortical RS alpha rhythms, associations between thalamic structure and alpha activity were examined. RS magnetoencephalography was obtained from 47 typically-developing children (TDC) and 41 children with ASD. RS alpha activity was measured using distributed source localization. Left and right thalamic volume measurements were also obtained. In both groups, the strongest alpha activity was observed in Calcarine Sulcus regions. In Calcarine regions, only TDC showed the expected association between age and alpha peak frequency. ASD had more alpha activity than TDC in regions bordering the Central Sulcus as well as parietal association cortices. In ASD, whereas greater left Central Sulcus relative alpha activity was associated with higher Social Responsiveness Scale (SRS) scores, greater Calcarine region relative alpha activity was associated with lower SRS scores. Although thalamic volume group differences were not observed, relationships between thalamic volume and Calcarine alpha power were unique to TDC. The present study also identified a failure to shift peak alpha frequency as a function of age in primary alpha-generating areas in children with ASD. Findings suggested that increased RS alpha activity in primary motor and somatosensory as well as parietal multimodal areas-with increased alpha thought to reflect greater inhibition-might impair the ability to identify or interpret social cues. Finally, to our knowledge, this is the first study to report associations between thalamic volume and alpha power, an association observed only in TDC. The lack of thalamic and alpha associations in ASD suggests thalamic contributions to RS alpha abnormalities in ASD.