Intron 12 in NTRK3 is associated with bipolar disorder
Intron 12 in NTRK3 is associated with bipolar disorder
复制标题
DOI：
10.1016/j.psychres.2010.05.011
复制
发表时间：
2011-02-28
影响因子：
11.3
通讯作者：
Djurovic, Srdjan
中科院分区：
文献类型：
--
作者：
Athanasiu, Lavinia;Mattingsdal, Morten;Djurovic, Srdjan
基于神经营养因子在大脑发育和可塑性中的重要作用以及精神分裂症与神经营养酪氨酸激酶受体 3 (NTRK3) 基因之间关联的报道，我们研究了双相情感障碍与 NTRK3 多态性的关联。最近，我们的小组报告了 NTRK3 多态性与海马功能和精神分裂症可能存在关联的证据。在本研究中，我们使用了挪威同质病例对照样本（TOP 研究），该样本由 194 名诊断为双相情感障碍的患者和 336 名健康对照组成，这些对照在 Affymetrix 全基因组人类 SNP 阵列 6.0 上进行了基因分型。总共对 149 个标记进行了 SNP 与疾病关联的研究。超过 20 个标记的多态性名义上与双相情感障碍相关，涵盖内含子 5 到内含子 12。有趣的是，我们的标记似乎位于精神分裂症、早发性重度抑郁症和饮食失调中报道的连锁区域附近或内部，支持了一些基因影响风险超出传统诊断界限的假设。 (C) 2010 Elsevier Ireland Ltd. 保留所有权利。
Based on the important role of neurotrophic factors in brain development and plasticity and reports of association between schizophrenia and the gene neurotrophic tyrosine kinase receptor 3 (NTRK3), we investigated associations of bipolar disorder with polymorphisms in NTRK3. Recently, our group reported evidence for a possible association of NTRK3 polymorphisms with hippocampal function and schizophrenia. In the present study, we used a homogenous Norwegian case-control sample (the TOP study) consisting of 194 patients diagnosed with bipolar disorder and 336 healthy controls genotyped on the Affymetrix Genome-wide Human SNP Array 6.0. In total 149 markers were investigated for SNP-disease association. Polymorphisms in over 20 markers were nominally associated with bipolar disorder, covering intron 5 to intron 12. Interestingly, our markers appeared to be located close or within the linkage regions reported in schizophrenia, early-onset major depressive disorder and eating disorder, supporting the hypothesis that some genes influence risk beyond traditional diagnostic boundaries. (C) 2010 Elsevier Ireland Ltd. All rights reserved.