Prevalence and Risk Factors of Cerebral Small Vessel Disease in a Chinese Population-Based Sample.
Prevalence and Risk Factors of Cerebral Small Vessel Disease in a Chinese Population-Based Sample.
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中国人群脑小血管疾病的患病率和危险因素
DOI：
10.5853/jos.2017.02110
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发表时间：
2018-05
影响因子：
8.2
通讯作者：
Zhu YC
中科院分区：
文献类型：
--
作者：
Han F;Zhai FF;Wang Q;Zhou LX;Ni J;Yao M;Li ML;Zhang SY;Cui LY;Jin ZY;Zhu YC
中国地区一般人群脑性小血管病的流行病学资料缺乏。我们报告了中国社区样本中腔隙、脑白质高强度(WMH)和脑微出血(CMBS)的患病率，并与其他研究结果进行了比较。这是对《中国》中以人口为基础的顺义研究的横断面分析。共有1211名无中风的参与者(平均年龄55.6±9.3岁；37.4%的男性)有3特斯拉(3T)磁共振图像被纳入这项分析。评估了人口统计学信息和危险因素数据。评估了腔隙、WMH和CMBS的总体和特定年龄段的患病率。通过多元Logistic回归分析心血管危险因素与这些病变的存在之间的关系。我们的研究显示腔隙的患病率为14.5%，脑室周围高信号(PVH)的患病率为72.1%，深层白质高信号(DWMH)的患病率为65.4%，CMBS的患病率为10.6%。与其他以社区为基础的样本相比，相同年龄组的个体表现出更高的腔隙负担和相对较低的CMBS患病率。高龄与这些CSVD标记物的患病率独立相关，而高血压的存在增加了深部或幕下部位腔隙、PVH/DWMH和CMBS的风险。在中国人群中观察到了更高的腔隙负担，但CMBS的患病率相对较低。这一显著的结果突显了中国预防CSVD的挑战。中国人患CSVD的危险因素与其他人群相似。
Epidemiological data of cerebral small vessel disease (CSVD) in the general population of China are lacking. We report on the prevalence of lacunes, white matter hyperintensity (WMH), and cerebral microbleeds (CMBs) in a community-based sample in China and compare the results with those of other studies. This was a cross-sectional analysis of the population-based Shunyi Study in China. A total of 1,211 stroke-free participants (mean age, 55.6±9.3 years; 37.4% men) with available 3 Tesla (3T) magnetic resonance images were included in this analysis. Demographic information and risk factor data were assessed. The overall and age-specific prevalence of lacunes, WMH, and CMBs was evaluated. Associations between cardiovascular risk factors and the presence of these lesions were analyzed by multiple logistic regression. Our study showed a prevalence of 14.5% for lacunes, 72.1% for periventricular hyperintensity (PVH), 65.4% for deep white matter hyperintensity (DWMH), and 10.6% for CMBs. When compared with other community-based samples, individuals in the same age group showed a higher burden of lacunes and a relatively lower prevalence of CMBs. Advanced age was independently associated with the prevalence of these CSVD markers, while the presence of hypertension increased the risk of lacunes, PVH/DWMH, and CMBs in deep or infratentorial locations. A higher burden of lacunes but a relatively lower prevalence of CMBs was observed in this Chinese population. This notable result highlights the challenge of CSVD prevention in China. Chinese have a risk factor profile for CSVD similar to those in other populations.