Actinofuranones A and B, polyketides from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales)
Actinofuranones A and B, polyketides from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales)
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DOI：
10.1021/np050402q
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发表时间：
2006-03-01
影响因子：
5.1
通讯作者：
Fenical, W
中科院分区：
文献类型：
--
作者：
Cho, JY;Kwon, HC;Fenical, W
从一株海洋链霉菌CNQ 766的培养物中分离得到两个新的聚酮化合物：放线呋喃酮A（1）和B（2）。1和2的结构通过核磁共振和其他光谱数据的解释和化学衍生化进行了鉴定。根据NOE数据和邻位H-1-H-1偶合常数对这些新分子的相对立体化学进行了归属，同时用改进的Mosher方法确定了不对称中心的绝对构型.
Two new polyketides, actinofuranones A (1) and B (2), were isolated from the culture extract of a marine-derived Streptomyces strain designated CNQ766. The structures of 1 and 2 were elucidated by interpretation of NMR and other spectroscopic data and by chemical derivatization. The relative stereochemistries of these new molecules were assigned on the basis of analysis of NOE data and vicinal H-1-H-1 coupling constants, while the absolute configurations of the asymmetric centers were determined using the modified Mosher's method.