Cell activation by Toll-like receptors: role of LBP and CD14
Cell activation by Toll-like receptors: role of LBP and CD14
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DOI：
10.1179/096805104225006273
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发表时间：
2004-01-01
期刊：
影响因子：
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通讯作者：
Kurt-Jones, EA
中科院分区：
文献类型：
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作者：
Finberg, RW;Re, F;Kurt-Jones, EA
Toll样受体（TLR）家族的成员已被证明在通过多种微生物配体激活细胞中是重要的。TLR被认为是介导哺乳动物细胞和微生物病原体相遇后的“识别事件”。在对细菌脂多糖（LPS）的应答的情况下，很明显，这些细胞表面蛋白启动细胞活化以产生细胞因子所必需的事件的能力取决于“辅助蛋白”，例如模式识别蛋白CD 14和脂多糖结合蛋白（LBP）。虽然这些蛋白质在LPS特异性反应中的作用已经确定，但它们在其他TLR反应中的作用尚未确定，但它对理解这些事件以及潜在地设计新的治疗策略很重要。在这里，我们报告的作用，这些蛋白质的反应酵母酵母聚糖。定义了这种应答的要求（与对LPS的应答不同，它是对颗粒抗原的应答）和其他血清蛋白的作用。
Members of the Toll-like receptor (TLR) family have been shown to be important in the activation of cells by a variety of microbial ligands. TLRs are thought to mediate the 'recognition event' that follows an encounter between a mammalian cell and a microbial agent. In the case of the response to bacterial lipopolysaccharide (LPS), it is clear that the ability of these cell surface proteins to initiate the events necessary for activation of cells to produce cytokines is dependent upon 'accessory proteins' such as the pattern recognition protein CD14 and the lipopolysaccharide binding protein (LBP). While the role of these proteins in the LPS-specific response is defined, their role in other TLR responses has not been defined, but it is important in understanding these events and, potentially, in designing new therapeutic strategies. Here we report on the role of these proteins in the response to yeast zymosan. The requirements for this response (which unlike the response to LPS is a response to a particulate antigen) and the role of other serum proteins are defined.