Minimally manipulated adipose derived mesenchymal stromal cells and osteoarthritis: A narrative review.
Minimally manipulated adipose derived mesenchymal stromal cells and osteoarthritis: A narrative review.
复制标题
微小操纵的脂肪衍生的间充质基质细胞和骨关节炎：叙事评论。
DOI：
10.23750/abm.v93i1.11102
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发表时间：
2022-03-14
期刊：
影响因子：
--
通讯作者：
Zmerly H
中科院分区：
文献类型：
--
作者：
Akkawi I;Draghetti M;Zmerly H
由于其再生能力和抗炎作用，人间充质基质细胞 (MSC) 已越来越多地用于治疗骨关节炎 (OA) 相关的疼痛和功能障碍。脂肪来源的 MSC 的特点是数量丰富、易于获取、分离程序简单、吸脂基质细胞产量高、细胞增殖更快以及收获过程中的疼痛和发病率较低。这些细胞通常是通过酶法从脂肪组织中衍生出来的，但这种技术存在复杂的监管问题。为了解决这个问题，人们发明了一种新技术来提取和处理脂肪组织而不进行扩增，并使用酶来生产自体微操作脂肪来源的间充质干细胞。最近的研究证实，这种治疗方法是治疗 OA 患者疼痛和改善关节功能的一种有效且有前景的方法，并且在中短期随访中并发症的比例非常低。 ()
Human mesenchymal stromal cells (MSCs) have increasingly been used to treat osteoarthritis (OA) related pain and dysfunction, due to their capacity for regeneration and anti-inflammatory effects. Adipose-derived MSCs are characterized by their abundance, ease of access, easy isolation procedures, high lipoaspirate stromal cell production, quicker multiplication of cells, and less pain and morbidity during harvesting. These cells are typically enzymatically derived from adipose tissue but this technique has complicated regulatory problems. To address this problem, a new technique has been created to extract and process adipose tissue without expansion and the use of enzymes to produce autologous minimally manipulated adipose-derived MSCs. Recent studies have confirmed that this treatment is an effective and promising method for treating pain and improving joint function in patients affected by OA with a very low percentage of complications at short to mid-term follow-up. ()