Nanostructure-Mediated Transport of Biologics across Epithelial Tissue: Enhancing Permeability via Nanotopography
Nanostructure-Mediated Transport of Biologics across Epithelial Tissue: Enhancing Permeability via Nanotopography
复制标题
DOI：
10.1021/nl3037799
复制
发表时间：
2013-01-01
期刊：
影响因子：
10.8
通讯作者：
Desai, Tejal A.
中科院分区：
文献类型：
--
作者：
Kam, Kimberly R.;Walsh, Laura A.;Desai, Tejal A.
在这里，我们证明了纳米地形线索可以被用来使生物制品>；66 kDa能够跨上皮单分子层运输。当与上皮单分子层接触时，纳米结构薄膜疏松了上皮屏障，允许显著增加FITC-白蛋白、FITC-Ig G和模型治疗药物依那西普的转运。我们的工作强调了使用结合纳米拓扑术的药物输送系统来增加生物制品在上皮组织中的传输的潜力。
Herein, we demonstrate that nanotopographical cues can be utilized to enable biologics >66 kDa to be transported across epithelial monolayers. When placed in contact with epithelial monolayers, nanostructured thin films loosen the epithelial barrier and allow for significantly increased transport of FITC-albumin, FITC-IgG, and a model therapeutic, etanercept. Our work highlights the potential to use drug delivery systems which incorporate nanotopography to increase the transport of biologics across epithelial tissue.