Effects of inhaled nanoparticle-rich diesel exhaust on regulation of testicular function in adult male rats
Effects of inhaled nanoparticle-rich diesel exhaust on regulation of testicular function in adult male rats
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DOI：
10.1080/08958370802524381
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发表时间：
2009-07-01
影响因子：
2.1
通讯作者：
Suzuki, Akira K.
中科院分区：
文献类型：
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作者：
Li, ChunMei;Taneda, Shinji;Suzuki, Akira K.
我们研究了富含纳米颗粒的柴油机尾气（NR-DE）对生殖功能的影响。将8周龄雄性F344大鼠分为12个实验组，（15.37微克/立方米（3），2.27 × 10（5）个颗粒/厘米（3）），中等（36.35 μ g/m3，5.11 × 10（5）颗粒/cm（3））或高浓度（168.84 μ g/m3，1.36 × 10（6）颗粒/cm（3））或清洁空气中4、8或12周（5小时/天，5天/周）。NR-DE暴露4周或8周不影响体重;然而，与对照组相比，暴露于低浓度或高浓度NR-DE 12周的大鼠体重显著降低。在第4、8和12周，所有NR-DE暴露大鼠的睾丸、附睾、精囊和前列腺的相对重量均无显著增加。暴露于低浓度NR-DE的大鼠在4周时肾上腺相对重量显著增加。血浆促黄体生成素和促卵泡激素浓度无明显变化。与对照组相比，暴露于低或中等浓度NR-DE 4或8周后血浆睾酮浓度显著增加。与对照组相比，暴露于高浓度NR-DE 4周或中浓度或高浓度NR-DE 12周后，血浆免疫反应性（ir-）受体结合蛋白浓度显著增加。与对照组相比，暴露于低浓度NR-DE后4、8和12周睾丸睾酮浓度显著增加。与此相反，暴露于低或高浓度NR-DE，睾丸ir-rabbin浓度显着高于对照组，但仅在4周。这些结果表明，NR-DE吸入干扰男性生殖系统的内分泌活动。
We investigated the effects of nanoparticle-rich diesel exhaust (NR-DE) on reproductive function. Eight-week-old male F344 rats were divided into 12 experimental groups and exposed to either whole NR-DE at low (15.37 mu g/m(3), 2.27 x 10(5) particles/cm(3)), middle (36.35 mu g/m(3), 5.11 x 10(5) particles/cm(3)), or high (168.84 mu g/m(3), 1.36 x 10(6) particles/cm3) concentrations or clean air for 4, 8, or 12 weeks (5 hours/day, 5 days/week). NR-DE exposure for 4 or 8 weeks did not affect body weight; however, body weight was significantly decreased in rats exposed to low- or high-concentration NR-DE for 12 weeks compared to the control group. Relative weights of testes, epididymides, seminal vesicles, and prostate had increased non-significantly in all NR-DE-exposed rats at 4, 8, and 12 weeks. Adrenal gland relative weights were significantly increased at 4 weeks in rats exposed to low-concentration NR-DE. Plasma luteinizing hormone and follicle stimulating hormone concentrations did not change significantly. Plasma testosterone concentrations were significantly increased after exposure to low- or middle-concentration NR-DE for 4 or 8 weeks compared to controls. Plasma immunoreactive (ir-) inhibin concentrations were significantly increased after exposure to high-concentration NR-DE for 4 weeks or middle- or high-concentration NR-DE for 12 weeks compared to controls. Testicular testosterone concentrations were significantly increased at 4, 8, and 12 weeks after exposure to low-concentration NR-DE compared to controls. In contrast, with exposure to low- or high-concentration NR-DE, testicular ir-inhibin concentrations were significantly greater than in controls, but only at 4 weeks. These results suggest that NR-DE inhalation disrupts the endocrine activity of the male reproductive system.