The risk of gallbladder cancer from polyps in a large multiethnic series
The risk of gallbladder cancer from polyps in a large multiethnic series
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DOI：
10.1016/j.ejso.2008.01.036
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发表时间：
2009-01-01
期刊：
影响因子：
3.8
通讯作者：
Toogood, G. J.
中科院分区：
文献类型：
--
作者：
Aldouri, A. Q.;Malik, H. Z.;Toogood, G. J.
背景资料：本研究的目的是评估是否与印度民族背景的患者是在发展中国家的胆囊癌（GBC）的风险增加，如果他们被诊断为超声异常的gallades.Methods：1998年1月至2006年7月，137,655腹部超声检查进行了利兹教学医院方法，NHS信托。排除重复扫描和肾脏或盆腔疾病后，本分析纳入了71，431份报告。在其中的GBC的诊断已作出无组织学的患者已确定从数据库的北方和约克郡癌症登记和GBC的存在与超声胆囊abnormalities.Results：胆囊息肉（GBP）检测到3.3%的患者，这些都大于10毫米的情况下，0.1%。年龄在60岁以上、印度民族背景、单个GBP大于10、存在胆结石、胆囊壁严重增厚和不规则增厚与GBC的发生率较高独立相关。印度裔GBP患者恶性肿瘤的发生率明显高于白种人，分别为5.5%和0.08%，P <0.001。结论：印度裔GBP患者的存在与体型无关，是进一步检查和/或胆囊切除术的指征。(c)2008爱思唯尔有限公司保留所有权利。
Background: The aim of this study is assess whether patients with Indian ethnic background are at an increased risk of developing gallbladder cancer (GBC) if they have been diagnosed with ultrasonic abnormalities of the gallbladder.Methods: Between January 1998 and July 2006, 137,655 abdominal ultrasound examinations were performed in Leeds Teaching Hospitals Metho, NHS Trust. After the exclusion of repeat scans and those performed for renal or pelvic disease, 71,431 reports were included in this analysis. Patients in whom the diagnosis of GBC has been made without histology have been identified from the database of Northern and Yorkshire Cancer Registry and the presence of GBC was correlated with ultrasonic gallbladder abnormalities.Results: Gallbladder polyps (GBP) were detected in 3.3% of patients and these were larger than 10 mm in 0.1% of the cases. Age above 60 years, Indian ethnic background, single GBP larger than 10 trim, the presence of gallstones, severe gallbladder wall thickening and irregular thickening were independently associated with the higher odds of developing GBC. The prevalence of malignancy in those with GBP was significantly higher among patients with Indian ethnic background compared to Caucasian patients, 5.5% versus 0.08%, p < 0.001.Conclusions: The presence of GBP, irrelevant of size, amongst patients of Indian ethnic decent, is an indication for further investigation and/or cholecystectomy. (c) 2008 Elsevier Ltd. All rights reserved.