Double-blind- evaluation of bromperidol versus haloperidol treatment in chronic psychotic patients.
Double-blind- evaluation of bromperidol versus haloperidol treatment in chronic psychotic patients.
复制标题
慢性精神病患者中溴哌啶醇与氟哌啶醇治疗的双盲评估。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
R. Dom
中科院分区：
文献类型：
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作者：
M. Malfroid;L. Hens;P. Roosen;R. Dom
24例慢性精神病患者随机分为溴哌利多组和氟哌啶醇组。溴哌利多的平均剂量为4 - 8 mg，早晨一次摄入，氟哌啶醇为4 mg，每日两次。采用简明精神病量表（BPRS）、总体临床印象量表、不良反应量表、血液学和生化检查进行定期评估。溴哌利多似乎是一种有效的抗精神病药物，持续时间为24小时。与氟哌啶醇相比，它通过温和但明确的激活特性有利于社会融合。未观察到重大副作用。
Twenty four chronic psychotic patients were assigned at random to bromperidol or haloperidol. The mean dose for bromperidol was 4 to 8 mg in one intake in the morning and for haloperidol 4 mg given twice a day. Regular evaluation was performed by BPRS, global clinical impression, side-effects scale, hematological and biochemical screening. It appears that bromperidol is a potent antipsychotic drug with a duration of 24 h. Compared to haloperidol, it favours social integration by a mild but definite activating property. No major side-effects were observed.