Is it possible to be schizophrenic yet neuropsychologically normal?
Is it possible to be schizophrenic yet neuropsychologically normal?
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DOI：
10.1037/0894-4105.11.3.437
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发表时间：
1997-07-01
期刊：
影响因子：
2.4
通讯作者：
Jeste, DV
中科院分区：
文献类型：
--
作者：
Palmer, BW;Heaton, RK;Jeste, DV
本研究确定和特点的精神分裂症患者没有神经心理（NP）的损害。一个全面的NP电池管理171精神分裂症门诊患者和63名正常对照参与者。每个参与者的NP状态进行了分类，通过盲临床评级2经验丰富的神经心理学家，27%的精神分裂症患者被归类为NP正常。NP正常和NP受损的精神分裂症患者在大多数人口统计学、精神病学和功能特征方面相似，但NP正常患者的阴性症状和锥体外系症状较少，服用抗胆碱能药物较少，社会化更频繁，最近精神病住院的可能性较小。NP正常的精神分裂症患者的存在表明，精神分裂症的认知缺陷往往与潜在的病理生理可能是不同的，导致其核心精神病学特征。
This study identified and characterized a group of schizophrenic patients without neuropsychological (NP) impairment. A comprehensive NP battery was administered to 171 schizophrenic outpatients and 63 normal comparison participants. Each participant's NP status was classified through blind clinical ratings by 2 experienced neuropsychologists; 27% of the schizophrenics were classified as NP normal. The NP-normal and NP-impaired schizophrenics were similar in terms of most demographic, psychiatric, and functional characteristics, except that NP-normal patients had less negative and extrapyramidal symptoms, were on less anticholinergic medication, socialized more frequently, and were less likely to have had a recent psychiatric hospitalization. The existence of NP normal schizophrenics suggests that the pathophysiology underlying the cognitive deficits often associated with schizophrenia may be distinct from that causing some of its core psychiatric features.