Cardiovascular and autonomic nervous functions during acclimatization to hypoxia in conscious rats
Cardiovascular and autonomic nervous functions during acclimatization to hypoxia in conscious rats
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DOI：
10.1016/j.autneu.2004.11.007
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发表时间：
2005-02-07
影响因子：
2.7
通讯作者：
Kuwahara, M
中科院分区：
文献类型：
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作者：
Kawaguchi, T;Tsubone, H;Kuwahara, M
在清醒的 Sprague-Dawley 大鼠中研究了适应缺氧过程中心血管和自主神经功能变化的时间过程。将动物置于 12:12 小时明暗循环下并暴露于缺氧（1 atm，10% O-2）。植入的遥测发射器用于记录血压（BP）。在 21 天的时间内监测心率 (HR) 和血压的变化，并使用小波变换方法分析缺氧之前和期间的变化。缺氧1 h后HR、心率变异性的高频功率（HR-HF）和血压变异性的低频功率（BP-LF）均显着增加，而心率变异性的LF/HF比值没有变化。在最初的增加之后，HR 和 BP-LF 均被发现下降。缺氧第一天，HR和BP-LF值显着低于对照组大鼠，而HR-HF值较高。随后，这些值发生变化，在缺氧 14 天后与对照相似。此外，缺氧期间心率的昼夜变化幅度降低。这些结果表明，交感神经和副交感神经活动之间的一系列动态相互作用可能在适应缺氧过程中心血管功能的调节中发挥重要作用。 (C) 2004 Elsevier B.V. 保留所有权利。
The time courses of changes in cardiovascular and autonomic nervous functions during acclimatization to hypoxia were studied in conscious Sprague-Dawley rats. The animals were kept under a 12:12-h light dark cycle and exposed to hypoxia (1 atm, 10% O-2). Implanted telemetry transmitters were used to record blood pressure (BP). Changes in heart rate (HR) and BP were monitored over a 21-day period, and variations before and during hypoxia were analyzed using the wavelet transform method. The HR, high-frequency power of HR variability (HR-HF) and low-frequency power of BP variability (BP-LF) were all significantly increased after 1 h of hypoxia, whereas the LF/HF ratio of HR variability did not change. After this initial increase, both HR and the BP-LF were found to decrease. On the first day of hypoxia, HR and BP-LF values were significantly lower than those of the control rats, whereas the HR-HF was higher. Subsequently, these values altered so that they were similar to the control after 14 days of hypoxia. In addition, the amplitude of diurnal variation in HR was reduced during hypoxia. These results suggest that a sequence of dynamic interactions between sympathetic and parasympathetic nervous activities might have important roles in the regulation of cardiovascular function during acclimatization to hypoxia. (C) 2004 Elsevier B.V. All rights reserved.