Influence of Hemoglobin Level on Muscle and Physical Functions, Activities of Daily Living, and Quality of Life in Patients With Hematological Malignancies
Influence of Hemoglobin Level on Muscle and Physical Functions, Activities of Daily Living, and Quality of Life in Patients With Hematological Malignancies
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DOI：
10.1177/1534735419842196
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发表时间：
2019-04-05
影响因子：
2.9
通讯作者：
Okita, Minoru
中科院分区：
文献类型：
--
作者：
Fukushima, Takuya;Nakano, Jiro;Okita, Minoru
目的。恶性血液病患者通常表现为肌肉和身体功能下降，这是由疾病或相关治疗引起的。此外，恶性血液病患者很快就会出现低血红蛋白水平，这可能会影响肌肉和身体功能。本研究旨在探讨血液系统恶性肿瘤患者血红蛋白水平对肌肉和身体功能的影响。方法：研究方法。本研究采用横断面研究设计，纳入60例恶性血液病患者(平均年龄68.0±10.2岁，女性56.7%)，他们因化疗和放疗相关的副作用而住院，并接受了骨骼肌群(SMM)、肌肉力量、身体功能、日常生活能力(ADL)、心理状况和生活质量(QOL)的检查，包括身体症状。受试者根据血红蛋白水平分为3组：低(n=19)、中(n=20)和高(n=21)。对3组患者的评估项目进行比较。结果。3组间SMM差异无统计学意义。低血红蛋白组的疲劳感和呼吸困难程度明显高于高血红蛋白组，而肌力、ADLS和生活质量则显著低于高血红蛋白组。结论。血红蛋白水平不影响SMM；然而，在低血红蛋白水平的患者中，可以观察到肌肉无力、身体功能下降、疲劳和呼吸困难等身体症状，以及ADLS和生活质量下降。
Purpose. Patients with hematological malignancies often present with reduced muscle and physical functions, which are caused by the disease or related treatment. Moreover, patients with hematological malignancies rapidly develop low hemoglobin levels, and this may affect muscle and physical functions. This study aimed to identify the influence of hemoglobin levels on muscle and physical functions in patients with hematological malignancies. Methods. Using a cross-sectional study design, this study included 60 patients with hematological malignancies (mean age = 68.0 +/- 10.2 years, women 56.7%) who were hospitalized for chemotherapy- and radiotherapy-related side effects and underwent examination for skeletal muscle mass (SMM), muscle strength, physical function, activities of daily living (ADLs), psychological status, and quality-of-life (QOL), including physical symptoms. Participants were divided into 3 groups according to tertiles of hemoglobin levels: low (n = 19), middle (n = 20), and high (n = 21). Evaluation items were compared among the 3 groups. Results. There was no significant difference among the 3 groups in terms of SMM. The low hemoglobin group showed significantly higher values of fatigue and dyspnea and lower values of muscle strength, ADLs, and QOL than the high hemoglobin group. Conclusions. Hemoglobin levels did not affect SMM; however, muscle weakness, decrease in physical function, physical symptoms such as fatigue and dyspnea, and decline in ADLs and QOL were observed in patients with low hemoglobin levels.