Roseobacticides: small molecule modulators of an algal-bacterial symbiosis.
Roseobacticides: small molecule modulators of an algal-bacterial symbiosis.
复制标题
DOI：
10.1021/ja207172s
复制
发表时间：
2011-11-16
影响因子：
15
通讯作者：
Clardy, Jon
中科院分区：
文献类型：
--
作者：
Seyedsayamdost, Mohammad R.;Carr, Gavin;Kolter, Roberto;Clardy, Jon
海洋细菌与微藻在小分子介导下进行动态共生。最近一项对α-变形菌门大玫瑰杆菌分支的gallaecphaeobacter gallaecensis和大型藻华中发现的微型浮游植物Emiliania huxleyi的研究表明，E. huxleyi产生的藻类衰老信号促使细菌共生体产生新的杀藻剂——玫瑰杆菌。在本报告中，通过扩大潜在激发子的数量来检验这些发现的普遍性。这一扩展导致鉴定了9个玫瑰杆菌家族的新成员，罕见的细菌troponoid，这为它们的生物学作用和生物合成提供了见解。由额外的激发子和激发子不同的效率诱导的玫瑰菌剂水平的定性和定量变化支持了宿主靶向玫瑰菌剂生产的概念。新家族成员的结构是由杀菌剂核心的C3和C7位置的可变取代基作为多样化元素产生的，这表明杀菌剂是由芳香氨基酸的修饰和组合而成的。这些研究共同支持了一个模型，在这个模型中，藻类衰老将共生的细菌共生体转化为其宿主的机会主义寄生虫。
Marine bacteria and microalgae engage in dynamic symbioses mediated by small molecules. A recent study of Phaeobacter gallaeciensis, a member of the large roseobacter clade of α-proteobacteria, and Emiliania huxleyi, a prominent member of the microphytoplankton found in large algal blooms, revealed that an algal senescence signal produced by E. huxleyi elicits the production of novel algaecides, the roseobacticides, from the bacterial symbiont. In this report, the generality of these findings are examined by expanding the number of potential elicitors. This expansion led to the identification of nine new members of the roseobacticide family, rare bacterial troponoids, which provide insights into both their biological roles and their biosynthesis. The qualitative and quantitative changes in the levels of roseobacticides induced by the additional elicitors and the elicitors’ varied efficiencies support the concept of host-targeted roseobacticide production. Structures of the new family members arise from variable substituents at the C3 and C7 positions of the roseobacticide core as the diversifying elements and suggest that the roseobacticides result from modifications and combinations of aromatic amino acids. Together these studies support a model in which algal senescence converts a mutualistic bacterial symbiont into an opportunistic parasite of its hosts.
登录
查看更多内容
影响因子：
64.8
作者：
BATES, TS;CHARLSON, RJ;GAMMON, RH
通讯作者：
GAMMON, RH
影响因子：
5.2
作者：
HOLLIGAN, PM;FERNANDEZ, E;VANDERWAL, P
通讯作者：
VANDERWAL, P
影响因子：
3.9
作者：
Espineira, J. M.;Novo Uzal, E.;Pomar, F.
通讯作者：
Pomar, F.
影响因子：
56.9
作者：
Joint, I;Tait, K;Cámara, M
通讯作者：
Cámara, M
影响因子：
4.4
作者：
Ashen, JB;Goff, LJ
通讯作者：
Goff, LJ