Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial
Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial
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DOI：
10.3945/ajcn.2009.27600
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发表时间：
2009-07-01
影响因子：
7.1
通讯作者：
Kerstetter, Jane E.
中科院分区：
文献类型：
--
作者：
Kenny, Anne M.;Mangano, Kelsey M.;Kerstetter, Jane E.
背景：大豆食品含有几种可能影响骨骼的成分（大豆酮和氨基酸）。大豆作为改善绝经后期妇女骨矿物质密度（BMD）的一种手段的长期、大型临床试验很少。目的：我们的目标是评估饮食中大豆蛋白和/或大豆蛋白对绝经后期妇女骨骼健康的长期影响。设计：我们在131名年龄>60岁的健康非卧床妇女中进行了一项随机、双盲、安慰剂对照的临床试验。97名女性完成了试验。在1个月的基线期后，受试者被随机分配到4个干预组中的一个：大豆蛋白（18 g）+维生素B1片剂（105毫克异黄酮苷元当量）、大豆蛋白+安慰剂片、对照蛋白+异黄酮片和对照蛋白+安慰剂片。结果：两组之间蛋白粉和维生素丸的摄入量没有差异，对研究粉末和药丸的依从性为80- 90%。从基线到干预后1年，两组之间的BMD没有显著差异，雌马酚生产者和非雌马酚生产者之间的BMD变化也没有显著差异。结论：大豆蛋白和大豆黄酮（单独或联合使用）对老年妇女骨密度无明显影响，不能作为老年妇女保护骨骼健康的有效干预措施。膳食蛋白质和骨转换之间的负相关性表明，增加蛋白质摄入量可能会抑制骨转换。本试验在clinicaltrials.gov上注册为NCT 00668447。美国临床营养杂志2009; 90：234-42。
Background: Soy foods contain several components (isoflavones and amino acids) that potentially affect bone. Few long-term, large clinical trials of soy as a means of improving bone mineral density (BMD) in late postmenopausal women have been conducted.Objective: Our goal was to evaluate the long-term effect of dietary soy protein and/or soy isoflavone consumption on skeletal health in late postmenopausal women.Design: We conducted a randomized, double-blind, placebo-controlled clinical trial in 131 healthy ambulatory women aged >60 y. Ninety-seven women completed the trial. After a 1-mo baseline period, subjects were randomly assigned into 1 of 4 intervention groups: soy protein (18 g) + isoflavone tablets (105 mg isoflavone aglycone equivalents), soy protein + placebo tablets, control protein + isoflavone tablets, and control protein + placebo tablets.Results: Consumption of protein powder and isoflavone pills did not differ between groups, and compliance with the study powder and pills was 80-90%. No significant differences in BMD were observed between groups from baseline to 1 y after the intervention or in BMD change between equol and non-equol producers. However, there were significant negative correlations between total dietary protein (per kg) and markers of bone turnover (P < 0.05).Conclusions: Because soy protein and isoflavones (either alone or together) did not affect BMD, they should not be considered as effective interventions for preserving skeletal health in older women. The negative correlation between dietary protein and bone turnover suggests that increasing protein intakes may suppress skeletal turnover. This trial was registered at clinicaltrials.gov as NCT00668447. Am J Clin Nutr 2009; 90: 234-42.