Three-Component Cascade Synthesis of Fully Substituted Trifluoromethyl Pyrroles via a Cu(II)/Rh(III)-Promoted Aza-Michael Addition/Trifluoromethylation Cyclization/Oxidation Reaction
Three-Component Cascade Synthesis of Fully Substituted Trifluoromethyl Pyrroles via a Cu(II)/Rh(III)-Promoted Aza-Michael Addition/Trifluoromethylation Cyclization/Oxidation Reaction
复制标题
通过 Cu(II)/Rh(III) 促进的 Aza-Michael 加成/三氟甲基化环化/氧化反应三组分级联合成完全取代的三氟甲基吡咯
DOI：
10.1021/acs.joc.9b03470
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发表时间：
2020-06-19
影响因子：
3.6
通讯作者：
Peng, Yiyuan
中科院分区：
文献类型：
--
作者：
Ge, Junying;Ding, Qiuping;Peng, Yiyuan
开发了 1,3-烯炔、苯胺和 Togni-II 试剂的三组分级联反应，可在温和条件下产生具有高区域选择性的完全取代的三氟甲基吡咯。该转化通过 Cu(II)/Rh(IID 促进的级联氮杂迈克尔加成/三氟甲基化环化/氧化反应进行，得到三氟甲基吡咯衍生物作为初级产物。
A three-component cascade reaction of 1,3-enynes, anilines, and Togni-II reagent has been developed to give fully substituted trifluoromethyl pyrroles with high regioselectivity under mild conditions. The transformation proceeds through a Cu(II)/Rh(IID-promoted cascade aza-Michael addition/trifluoromethylation cydization/oxidation reaction, affording trifluoromethyl pyrrole derivatives as primary products.