Liver Cancer Survival: A Real World Observation of 45 Years with 32,556 Cases.
Liver Cancer Survival: A Real World Observation of 45 Years with 32,556 Cases.
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DOI：
10.2147/jhc.s321346
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发表时间：
2021
影响因子：
4.1
通讯作者：
Wang GR
中科院分区：
文献类型：
--
作者：
Chen JG;Zhu J;Zhang YH;Chen YS;Ding LL;Chen HZ;Shen AG;Wang GR
基于中国启东基于人群的癌症登记处过去 45 年的真实世界数据 (RWD)，探讨肝癌生存的长期趋势。 1972年至2016年期间登记了32,556名肝癌患者。采用主动和被动随访的混合方法。采用SPSS22软件采用生命表法进行生存分析。 Wilcoxon (Gehan) 统计数据被认为是一个重要的检验。使用SURV软件计算相对生存率，并通过Joinpoint回归程序估计其年度百分比变化（APC）。数据系列中观察到的1年、5年、10年和20年总体生存率（OS）分别为18.51%、6.28%、4.03%和2.84%，相对生存率（RS）分别为18.88%、6.95%、4.96%和4.49%。 24,338例男性病例中，5年OS率和RS率分别为5.93%和6.54%，8218例女性病例中，5年OS率和RS率分别为7.34%和8.15%，P值小于0.01。 1972-1986年、1987-2001年、2002-2016年三个15年期间肝癌生存率显着提高，5年OS率分别为2.02%、4.40%和10.76%，5年RS率分别为2.18%、4.83%和12.18%； 10年OS率和RS率分别为0.95%、3.00%和7.02%，而10年OS率和RS率分别为1.13%、3.65%和8.96%，呈现非常显着的上升趋势（P<0.01）。各年龄组之间存在显着差异（P<0.01）：55-64岁的患者表现出最佳的5年OS率和RS率，分别为8.44%和9.09%。启东市肝癌生存率存在显着的性别和年龄差异。 RWD表明该领域肝癌的生存率相对较低，但在过去的几十年里已经取得了很大的进步。
To explore the long-term trend of liver cancer survival, based on the real-world data (RWD) in the past 45 years from a population-based cancer registry, in Qidong, China. A number of 32,556 patients with liver cancer were registered during the period of 1972 to 2016. Mixed methods by active and passive follow-up were performed. Life table method was employed for survival analysis by SPSS22 software. Wilcoxon (Gehan) statistics was considered as a significant test. Relative survival was calculated by using SURV software, and its annual percent change (APC) was estimated by the Joinpoint Regression Program. The overall observed survival (OS) rates of 1-, 5-, 10-, and 20-year rates from the data series were 18.51%, 6.28%, 4.03%, and 2.84%, and their relative survival (RS) rates were 18.88%, 6.95%, 4.96%, and 4.49%, respectively. For 24,338 male cases, the 5-year OS and RS rates were 5.93% and 6.54%, and for 8218 female cases, 7.34% and 8.15%, respectively, with P values less than 0.01. Survival rates of liver cancer from three 15-year periods of 1972–1986, 1987–2001, and 2002–2016 have increased significantly, with 5-year OS rates of 2.02%, 4.40%, and 10.76%, 5-year RS rates of 2.18%, 4.83%, and 12.18%; 10-year OS and RS rates of 0.95%, 3.00%, and 7.02%, vs 1.13%, 3.65%, and 8.96%, respectively, showing a very significant upward trend (P<0.01). There are significant differences among age groups (P<0.01): those aged 55–64 demonstrated the best OS and RS rates of 5-year, being 8.44% and 9.09%, respectively. There are significant gender and age differences in the survival rate of liver cancer in Qidong. RWD indicates the relative lower survival rate of liver cancer in this area, but great improvement has been achieved over the past decades.