Transcortin: a corticosteroid-binding protein of plasma. II. Levels in various conditions and the effects of estrogens.
Transcortin: a corticosteroid-binding protein of plasma. II. Levels in various conditions and the effects of estrogens.
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Transcortin：血浆皮质类固醇结合蛋白。
DOI：
10.1172/jci103904
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发表时间：
1959
期刊：
影响因子：
--
通讯作者：
W. Slaunwhite
中科院分区：
文献类型：
--
作者：
A. Sandberg;W. Slaunwhite
最近几个实验室发表的证据表明，人类血浆中存在一种对皮质类固醇结合具有高亲和力的蛋白质，我们将其命名为transcortin（1-5）。尽管转肾上腺素的浓度远低于白蛋白，但前者与皮质醇的结合强度约为后者的6000倍(5)。因此，在生理条件下，大多数血浆皮质醇已被证明与转肾上腺素结合。血浆皮质醇水平约为30至40微克时，转肾上腺素似乎已饱和。%（4-5）。Daughaday（2,6）、Bush(3)、Upton和Bondy(4)以及我们自己(5)已经描述了糖皮质激素结合蛋白的一些特性。在之前的一篇论文中，我们报道了一种测量血浆中转甲素结合能力的方法，并表明它在孕妇血浆中增加(5)。由于转甲素的浓度可能在皮质醇的代谢和生物学效应中起重要作用，因此确定几种临床状态下的转甲素容量似乎是值得的。本文介绍了新生儿及其母亲血浆中传递素结合能力的数据；在不同年龄的正常儿童中；肝硬化患者；杂病患者；在服用了雌激素之后。
Evidence for the existence in human plasma of a protein with high affinity for the binding of corticosteroids, which we have named transcortin, has been recently published from several laboratories (1-5). Even though the concentration of transcortin is considerably lower than that of albumin, the former binds cortisol approximately 6,000 times as strongly as does the latter (5). Therefore, under physiological conditions most of the plasma cortisol has been shown to be bound to transcortin. Transcortin appears to be saturated at plasma levels of cortisol of approximately 30 to 40 ug. per cent (4-5). Some of the characteristics of the corticosteroid-binding protein have been described by Daughaday (2, 6), Bush (3), Upton and Bondy (4) and ourselves (5). In a previous paper we reported a method for measuring the binding capacity of transcortin in plasma and showed it to be increased in the plasma of pregnant women (5). Since the concentration of transcortin may play an important role in the metabolism and biological effects of cortisol, it appeared worthwhile to ascertain the transcortin capacity in several clinical states. Data are presented in this paper on the transcortin binding capacity in the plasma of newborn infants and their mothers; in normal children of various ages; in patients with cirrhosis of the liver; in patients with miscellaneous diseases; and following the administration of estrogenic substances.