Factors affecting adherence to treatment of psoriasis: comparing biologic therapy to other modalities
Factors affecting adherence to treatment of psoriasis: comparing biologic therapy to other modalities
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DOI：
10.3109/09546634.2011.607425
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发表时间：
2013-02-01
影响因子：
2.9
通讯作者：
Ormerod, Anthony D.
中科院分区：
文献类型：
--
作者：
Chan, Sue Ann;Hussain, Fawad;Ormerod, Anthony D.
目的：本研究评估了自我报告的牛皮癣患者对不同类型治疗的依从性以及影响依从性的因素。患者和方法：在皮肤科接受银屑病治疗的患者完成了一份关于每种治疗方法的依从性、自我评估银屑病面积和严重程度指数（SAPASI）和皮肤病生活质量指数（DLQI）的调查问卷。结果：共106例患者，局部治疗98例，口服全身治疗43例，光疗39例，生物治疗29例。自我报告的治疗依从性总体率为85.8%。治疗类型（局部治疗、口服全身治疗、光疗和生物治疗）与治疗组合次数和依从性之间存在显著关系。生物疗法的依从性排名为100%，其次是口服疗法96%，光疗93%，然后是局部治疗75%。太忙、受够了以及吸烟都会降低依从性。约56.8%的患者报告说，混乱的治疗使他们无法坚持下去。轻度银屑病患者和DLQI≤5的患者对局部治疗的依从性较差。结论：治疗类型（局部、全身、光疗和生物治疗）与联合治疗次数及依从性有显著关系。
Objectives: This study evaluated self-reported patient adherence to different types of treatment in psoriasis and factors that affect adherence. Patients and methods: Patients attending a Dermatology Department for treatments of psoriasis completed a questionnaire about adherence to each of their therapies, Self-assessed Psoriasis Area and Severity Index (SAPASI) and Dermatology Life Quality Index (DLQI). Results: Hundred and six patients participated, 98 on topical treatments, 43 on oral systemic therapies, 39 on phototherapy and 29 were on biologic therapies. The overall rate of self-reported treatment adherence was 85.8%. There was a significant relationship between the types of treatment (topical, oral systemic, phototherapy and biologic therapy) and the number of combinations of treatments and adherence. Adherence ranked significantly better on biologic therapies 100%, followed by oral therapy 96%, phototherapy 93% and then topical therapy 75%. Being too busy, being fed up and cigarette smoking were associated with reduced adherence. About 56.8% of patients reported that messiness of treatment prevented them from adhering. Patients with mild psoriasis and those with DLQI of 5 or less adhered less to topical therapy. Conclusions: There is a significant relationship between the types of treatment (topical, oral systemic, phototherapy and biologic therapy) and the number of combinations of treatments and adherence.