Xanthophyll epoxides, unlike β-carotene monoepoxides, are not detectibly absorbed by humans
Xanthophyll epoxides, unlike β-carotene monoepoxides, are not detectibly absorbed by humans
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DOI：
10.1093/jn/131.12.3212
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发表时间：
2001-12-01
影响因子：
4.2
通讯作者：
Olson, JA
中科院分区：
文献类型：
--
作者：
Barua, AB;Olson, JA
增加水果和蔬菜的摄入量与降低癌症和其他慢性疾病的风险有关。环氧类胡萝卜素广泛分布于自然界，是许多水果和蔬菜中主要的膳食类胡萝卜素。先前的研究表明，5,6-环氧- β -胡萝卜素被人体吸收良好，在诱导NB4细胞分化方面比β -胡萝卜素活性高得多。在人类食用的许多蔬菜和水果中，诸如新黄质、紫黄质和5,6-环氧叶黄素等黄酮类环氧化合物比环氧烃胡萝卜素含量更丰富。为了确定环氧叶黄素是否也被人体吸收，化学制备了叶黄素5,6-环氧叶黄素（taraxanthin）和玉米黄素5,6,5'6'-二氧化叶黄素（violaxanthin），溶解在玉米油中并口服给3名受试者。单次口服紫黄质或虫黄质9小时内血浆类胡萝卜素分析没有显示出任何紫黄质、虫黄质或它们的任何代谢产物。
Increased intake of fruits and vegetables is associated with reduced risk of cancer and other chronic diseases. Epoxycarotenoids are widely distributed in nature and constitute major dietary carotenoids in a number of fruits and vegetables. Previous studies have shown that beta -carotene 5,6-epoxide was absorbed well by humans, and was much more active than beta -carotene in inducing the differentiation of NB4 cells. Xanthophyll epoxides such as neoxanthin, violaxanthin and lutein 5,6-epoxide, are more abundant than epoxy-hydrocarbon carotenes in a number of vegetables and fruits that humans consume. To determine whether xanthophyll epoxides are also absorbed by humans, lutein 5,6-epoxide (taraxanthin) and zeaxanthin 5,6,5'6'-diepoxide (violaxanthin) were chemically prepared, dissolved in corn oil and orally administered to three human subjects. Analysis of plasma for carotenoids within 9 h after a single oral dose of either violaxanthin or taraxanthin failed to show any violaxanthin, taraxanthin or any of their metabolites.