Drug-metal interactions: copper(II) complex of the antidiabetic drug acetohexamide and pyridine.
Drug-metal interactions: copper(II) complex of the antidiabetic drug acetohexamide and pyridine.
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药物-金属相互作用：抗糖尿病药物乙酰己酰胺和吡啶的铜(II)络合物。
DOI：
10.1016/0162-0134(90)84012-e
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发表时间：
1990
影响因子：
3.9
通讯作者：
Pezeshk,V
中科院分区：
文献类型：
--
作者：
Pezeshk,A;Pezeshk,V
报道了4-乙酰基-N-[（环己基氨基）羰基]苯磺酰胺（acetohexamide）与吡啶的铜（II）配合物的制备、光谱性质和晶体结构。合成了Cu（AH）_2（py）_2（AH =乙酰己脲，py =吡啶）配合物，并通过X射线衍射和电子自旋共振（ESR）对其进行了表征。配合物属单斜晶系，P21/a空间群，a = 17.412（6），B= 9.039（2），c= 26.531（10）°，β = 102.24（2）°，Z = 4。最终的细化使用3892个独特的反射，并给出0.0646的R值。铜原子被四个氮原子以正方形平面排列包围，两个来自乙酰己酰胺配体（Cu <$N = 2.009 <$），两个来自吡啶分子（Cu <$N = 2.016 <$），呈反式几何构型。ESR数据支持铜与dx 2 − y2轨道上的未成对电子有类似的配位行为（g> g>ge）。
The preparation, spectral properties, and crystal structure of a copper(II) complex of 4-acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide, which is known as acetohexamide, and pyridine are reported. The complex Cu(AH)2(py)2, where AH = acetohexamide and py = pyridine, was prepared and characterized by X-ray and ESR. The complex is monoclinic, space groupP21/a, witha= 17.412(6),b= 9.039(2),c= 26.531(10) Å , β = 102.24(2)°, andZ= 4. The final refinement used 3892 unique reflections and gave anRvalue of 0.0646. The copper atom is surrounded by four nitrogen atoms in a square-planar arrangement, two from the acetohexamide ligands (CuN = 2.009 Å) and two from the pyridine molecules (CuN = 2.016 Å) in a trans geometry. The ESR data support a similar coordination behavior of the copper (g∥>g⊥>ge) with the unpaired electron in the dx2−y2orbital.