Magnetic resonance macromolecular agents for monitoring tumor microvessels and angiogenesis inhibition
Magnetic resonance macromolecular agents for monitoring tumor microvessels and angiogenesis inhibition
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DOI：
10.1097/01.rli.0000186565.21375.88
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发表时间：
2006-03-01
影响因子：
6.7
通讯作者：
van Dijke, CF
中科院分区：
文献类型：
--
作者：
Preda, A;van Vliet, M;van Dijke, CF
使用大分子造影剂的动态对比增强磁共振成像（DCE-MRI）能够根据造影剂在正常和病理组织中的差异分布评估肿瘤血管系统。形态学和功能特性的定量分析可以为组织血管生成提供有用的诊断见解。在一系列恶性肿瘤类型中，已经通过实验证明了使用大分子药物增强的MRI来表征肿瘤微血管。DCE-MRI数据的动力学分析可用于估计微血管通透性和肿瘤血容量。通过测量这些功能性肿瘤特性，可以获得单个肿瘤微循环的准确、无创和定量描述，从而提高癌症诊断、治疗和随访的成像检查的特异性。MRI无创性评价肿瘤血管生成可用于良恶性肿瘤的鉴别诊断，也可为抗肿瘤治疗的体内监测提供手段。在这篇综述中，潜在的临床应用和各种大分子造影剂的局限性，适用于肿瘤血管生成的评价，有和没有药物干预，进行了讨论。
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using macromolecular contrast media enables assessments of the tumor vasculature based on the differential distribution of the contrast agent within normal and pathologic tissues. Quantitative assays of both morphologic and functional properties can provide useful diagnostic insight into tissue angiogenesis. The use of MRI enhanced with macromolecular agents for the characterization of tumor microvessels has been experimentally demonstrated in a range of malignant tumor types. Kinetic analysis of DCE-MRI data can be used to estimate microvascular permeability and tumor blood volume. By measuring these functional tumor properties, an accurate, noninvasive, and quantitative description of the microcirculation of individual tumors can be acquired, improving the specificity of imaging examinations for cancer diagnosis and for treatment and follow up. The noninvasive MRI assessment of tumor angiogenesis can be applied in the diagnostic differentiation between benign and malignant tumors and can also provide means for in vivo monitoring of antitumor therapy. In this review, the potential clinical applications and limitations of various macromolecular contrast agents applied for evaluations of tumor angiogenesis, with and without drug interventions, are discussed.