Reproductive Health Choices for Young Adults With Sickle Cell Disease or Trait Randomized Controlled Trial Immediate Posttest Effects
Reproductive Health Choices for Young Adults With Sickle Cell Disease or Trait Randomized Controlled Trial Immediate Posttest Effects
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DOI：
10.1097/nnr.0b013e3182a0316b
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发表时间：
2013-09-01
期刊：
影响因子：
2.5
通讯作者：
Thompson, Alexis A.
中科院分区：
文献类型：
--
作者：
Wilkie, Diana J.;Gallo, Agatha M.;Thompson, Alexis A.
背景：患有镰状细胞病（SCD）或镰状细胞性状（SCT）的人可能不知道做出明智的生殖健康决策所需的遗传信息。 CHOICES 是一种基于网络的多媒体教育干预措施，提供有关生殖选择和后果的信息，以帮助患有 SCD 或 SCT 的人确定和实施明智的育儿计划。必须评估 CHOICES 与常规护理相比的功效。 目的：目的是比较 CHOICES 与注意力控制常规护理干预措施（电子书）对 SCD/SCT 相关生殖健康知识、意图和行为的即时测试后效果。方法：在一项随机对照研究中，我们从诊所、社区环境和在线网络中招募了 SCD/SCT 受试者，并在方便的地点收集了 234 名 SCD 受试者的数据（n = 136) 或 SCT (n = 98)。他们的年龄从18岁到35岁不等； 65% 是女性，94% 是非裔美国人。受试者在干预前和干预后立即完成镰状细胞生殖知识、意图和行为的测量。结果：与电子书组相比，当预测试分数受到控制时，CHOICES 组的平均知识得分和报告养育计划以避免 SCD 或 SCD 和 SCT 的概率显着更高。对意图和计划行为的影响并不显着。选择组的意图和计划行为显示出显着变化，而电子书组的意图和计划行为没有显着变化，但他们的计划行为有显着差异。 讨论：初步疗效结果令人鼓舞，但需要计划的加强课程和结果随访，以确定对 SCD/SCT 患者生殖健康知识、意图和实际行为的持续干预效果。
Background: People with sickle cell disease (SCD) or sickle cell trait (SCT) may not have information about genetic inheritance needed for making informed reproductive health decisions. CHOICES is a Web-based, multimedia educational intervention that provides information about reproductive options and consequences to help those with SCD or SCT identify and implement an informed parenting plan. Efficacy of CHOICES compared with usual care must be evaluated.Objective: The purpose was to compare immediate posttest effects of CHOICES versus an attention-control usual care intervention (e-Book) on SCD-/SCT-related reproductive health knowledge, intention, and behavior.Methods: In a randomized controlled study, we recruited subjects with SCD/SCT from clinics, community settings, and online networks with data collected at sites convenient to the 234 subjects with SCD (n = 136) or SCT (n = 98). Their ages ranged from 18 to 35 years; 65% were women, and 94% were African American. Subjects completed a measure of sickle cell reproductive knowledge, intention, and behavior before and immediately after the intervention.Results: Compared with the e-Book group, the CHOICES group had significantly higher average knowledge scores and probability of reporting a parenting plan to avoid SCD or SCD and SCT when pretest scores were controlled. Effects on intention and planned behavior were not significant. The CHOICES group showed significant change in their intention and planned behavior, whereas the e-Book group did not show significant change in their intention, but their planned behavior differed significantly.Discussion: Initial efficacy findings are encouraging but warrant planned booster sessions and outcome follow-ups to determine sustained intervention efficacy on reproductive health knowledge, intention, and actual behavior of persons with SCD/SCT.