MHCII, Tlr4 and Nramp1 genes control host pulmonary resistance against the opportunistic bacterium Pasteurella pneumotropica
MHCII, Tlr4 and Nramp1 genes control host pulmonary resistance against the opportunistic bacterium Pasteurella pneumotropica
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MHCII、Tlr4 和 Nramp1 基因控制宿主肺部对机会性细菌嗜肺巴氏杆菌的抵抗力
DOI：
10.1189/jlb.69.3.381
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发表时间：
2001
影响因子：
5.5
通讯作者：
M. Hart
中科院分区：
文献类型：
--
作者：
S. Chapes;D. Mosier;A. D. Wright;M. Hart
MHCII、Tlr 4和Nramp 1基因在肺免疫中各自独立地重要。为了确定这些基因对宿主抗性的影响，用条件性细菌嗜肺巴斯德氏菌对携带这三种基因的功能等位基因的各种组合的小鼠进行实验性攻击。MHCII-/-、Tlr 4d/d和Nramp 1 s/s小鼠对实验性感染P.与仅携带这些基因之一的功能性等位基因的小鼠相比，嗜肺假单胞菌从被攻击的小鼠的肺中培养，并且肺炎的严重程度与分离的细菌的数量强烈相关。具有MHCII-/-Tlr 4 n/n基因型的小鼠比MHCII+/+、Tlr 4d/d小鼠对肺炎的易感性更低。有趣的是，Nramp 1基因对宿主抗性的贡献仅在功能性MHCII或Tlr 4基因不存在的情况下是明显的。这些数据表明，MHCII，Tlr 4和Nramp 1基因是重要的肺部细菌耐药性。
MHCII, Tlr4, and Nramp1 genes are each independently important in pulmonary immunity. To determine the effect of these genes on host resistance, mice carrying various combinations of functional alleles for these three genes were experimentally challenged with the opportunistic bacterium, Pasteurella pneumotropica. MHCII‐/‐,Tlr4d/d, and Nramp1s/s mice were significantly more susceptible to experimental infections byP. pneumotropica after intranasal challenge compared to mice carrying functional alleles at only one of those genes. P. pneumotropica were cultured from the lungs of challenged mice, and the severity of the pneumonia strongly correlated with the number of isolated bacteria. Mice with the genotype MHCII‐/‐Tlr4n/n genotype were less susceptible to pneumonia than MHCII+/+, Tlr4d/d mice. It is interesting that the Nramp1 gene contribution to host resistance was apparent only in the absence of functional MHCII or Tlr4 genes. These data suggest that MHCII,Tlr4, and Nramp1 genes are important to pulmonary bacterial resistance.
患有鸟分枝杆菌细胞内肺病的女性的 NRAMP1 和 IFN-gammaR1 基因分析。
DOI：
10.1164/ajrccm.157.2.9706012
发表时间：
1998
期刊：
American journal of respiratory and critical care medicine.
影响因子：
--
作者：
Huang,JH;Oefner,PJ;Adi,V;Ratnam,K;Ruoss,SJ;Trako,E;Kao,PN
通讯作者：
Kao,PN
脂质 A 相关蛋白在重组干扰素-γ引发的 C3H/HeJ 巨噬细胞激活至完全杀肿瘤状态的过程中提供了替代的“第二信号”。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hogan,MM;Vogel,SN
通讯作者：
Vogel,SN