Phenylethylamine-like properties of baclofen.
Phenylethylamine-like properties of baclofen.
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巴氯芬具有类似苯乙胺的特性。
DOI：
10.1159/000117968
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发表时间：
1983
影响因子：
3.2
通讯作者：
A. Mosnaim
中科院分区：
文献类型：
--
作者：
M. Wolf;S. Keener;P. Mathis;A. Mosnaim
巴氯芬治疗仅改善躯干迟发性运动障碍患者的运动障碍。然而，不良副作用的出现并不能保证继续使用该药治疗。巴氯芬对精神分裂症没有任何治疗效果，而且观察到精神状况有恶化的趋势，表现为易怒、攻击性和明显的幻听。巴氯芬对迟发性运动障碍和精神分裂症的作用可以用它的苯乙胺样特性来解释。
Baclofen therapy resulted in improvement of dyskinesias only in patients with trunkal tardive dyskinesia. However, the appearance of undesirable side effects did not warrant continuation of treatment with this drug. Baclofen did not have any therapeutic effect in schizophrenia and moreover a trend towards a worsening of the psychiatric conditions with irritability, assaultiveness and prominent auditory hallucinations was observed. The effects of baclofen on tardive dyskinesia and schizophrenia can be explained in terms of its phenylethylamine-like properties.