Preoperative prediction of survival in resectable gallbladder cancer by a combined utilization of CA 19-9 and carcinoembryonic antigen
Preoperative prediction of survival in resectable gallbladder cancer by a combined utilization of CA 19-9 and carcinoembryonic antigen
复制标题
DOI：
10.3760/cma.j.issn.0366-6999.20131734
复制
发表时间：
2014-06-20
影响因子：
6.1
通讯作者：
Cai Xiujun
中科院分区：
文献类型：
--
作者：
Yu Tunan;Yu Hong;Cai Xiujun
目前，胆囊癌（GBC）常用的分期系统都是基于术后病理检查。在接受治疗性手术的患者中，没有有效的方法来预测术前的生存。在这项研究中，我们探讨了是否联合使用两种肿瘤生物标志物，即碳水化合物抗原19-9 （CA 19-9）和癌胚抗原（CEA），可以在术前预测可切除的GBC的生存。方法对73例行根治性GBC手术的患者进行研究。回顾性分析临床病理资料。结果经多因素分析，CA 19-9升高(P
Background Currently, all frequently used staging systems in gallbladder cancer (GBC) are based on postoperative pathological examinations. In patients undergoing curative operation, there is no effective method to predict survival preoperatively. In this study, we explored whether a combined utilization of two tumor biomarkers, namely carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA), could give a preoperative prediction of survival in resectable GBC.Methods Seventy-three patients who underwent radical resection for GBC were included in this study. A retrospective analysis of clinical pathological data was conducted.Results By multivariate analysis, CA 19-9 elevation (P