Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma
Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma
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DOI：
10.1111/j.1365-2265.2009.03537.x
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发表时间：
2009-10-01
影响因子：
3.2
通讯作者：
Shong, Young Kee
中科院分区：
文献类型：
--
作者：
Kim, Eui Young;Kim, Won Gu;Shong, Young Kee
慢性淋巴细胞性甲状腺炎（CLT）对甲状腺乳头状癌（PTC）患者预后的影响仍有争议。我们评估了共存的CLT对预后的影响和共存的CLT与临床病理学参数的关联。DesignA回顾性研究，平均随访时间为70个月。患者和measurementsPatients与PTC谁接受了甲状腺全切除术，然后在1995年和2003年之间的I-131残留消融在峨山医疗中心，首尔，韩国被招募。结果1441例患者中，214例（14个中心点，9%）同时存在CLT。CLT患者中女性比例高于非CLT患者（P < 0，中点01）。CLT患者的平均肿瘤大小小于无CLT患者（2个中心点0 +/- 1个中心点2 vs. 2个中心点2 +/- 1个中心点4 cm; P = 0个中心点02）。151例（12个中心点3%）未接受CLT的患者复发，而14例（7个中心点1%）接受CLT的患者在随访期间复发（P = 0，中心点016）。在颈部淋巴结转移患者中，合并CLT的患者的复发率明显低于未合并CLT的患者（P = 0，中心点012）。然而，这种关联失去了调整其他临床病理学预测recursions.ConclusionsIn这项研究中，CLT通常与PTC，并与小尺寸的原发性肿瘤在介绍多变量分析。CLT还与随访期间复发风险降低相关，尽管在调整其他预后因素后并不显著。
P>ObjectiveThe effect of coexistent chronic lymphocytic thyroiditis (CLT) on prognosis in papillary thyroid carcinoma (PTC) patients remains controversial. We evaluated the influence of coexistent CLT on prognostic outcome and the association of coexistent CLT with clinicopathological parameters.DesignA retrospective study with a median follow-up of 70 months.Patients and measurementsPatients with PTC who underwent total thyroidectomy followed by I-131 remnant ablation between 1995 and 2003 at Asan Medical Center, Seoul, Korea were enrolled. CLT was diagnosed histopathologically.ResultsAmong 1441 patients, 214 (14 center dot 9%) had coexistent CLT. A greater female preponderance was noted in the patients with CLT compared with those without CLT (P < 0 center dot 01). Mean tumour size in the patients with CLT was smaller than that in patients without CLT (2 center dot 0 +/- 1 center dot 2 vs. 2 center dot 2 +/- 1 center dot 4 cm; P = 0 center dot 02). One hundred and fifty-one (12 center dot 3%) patients without CLT had recurrence, whereas 14 (7 center dot 1%) patients with CLT had recurrence during the follow-up period (P = 0 center dot 016). In patients with cervical lymph node metastases, those with coexistent CLT showed a significantly lower recurrence rate than those without CLT (P = 0 center dot 012). However, this association was lost on multivariate analysis adjusting for other clinicopathological predictors for recurrence.ConclusionsIn this study, CLT was commonly associated with PTC and was associated with smaller size of the primary tumour at presentation. CLT was also associated with a reduced risk of recurrence during follow-up, although this was not significant after adjustment for other prognostic factors.