Arctic and Arctic-like rabies viruses: distribution, phylogeny and evolutionary history
Arctic and Arctic-like rabies viruses: distribution, phylogeny and evolutionary history
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DOI：
10.1017/s095026880700903x
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发表时间：
2008-04-01
影响因子：
4.2
通讯作者：
Rupprecht, C. E.
中科院分区：
文献类型：
--
作者：
Kuzmin, I. V.;Hughes, G. J.;Rupprecht, C. E.
对41个新测序的北极和类似北极的狂犬病病毒分离株进行了基因比较，并与GenBank中提供的那些进行了比较。确定了北极病毒的四个系统发育谱系。北冰洋1号病毒在安大略省传播，北冰洋2号病毒在西伯利亚和阿拉斯加传播，北冰洋3号病毒在极地传播，新描述的北冰洋4号在阿拉斯加本地传播。西伯利亚现有的最古老的分离株(1950-1960年间)属于北极2号和北极3号谱系，与当代病毒有98个中心点6-99个中心点2%的N基因同源性。在南亚和中东(类北极-1)和东亚(类北极-2)发现了两种类似北极的病毒谱系。一棵按时间标尺的树表明，北极和类似北极病毒的最近共同祖先(TMRCA)的时间可以追溯到1255年到1786年之间。北极病毒的进化是通过向北传播的方式发生的。类北极病毒2的谱系首先分化，而北极病毒与类北极1病毒共享TMRCA。
Forty-one newly sequenced isolates of Arctic and Arctic-like rabies viruses, were genetically compared to each other and to those available from GenBank. Four phylogenetic lineages of Arctic viruses were identified. Arctic-1 viruses circulate in Ontario, Arctic-2 viruses circulate in Siberia and Alaska, Arctic-3 viruses Circulate circumpolarly, and a newly described lineage Arctic-4 circulates locally in Alaska. The oldest available isolates from Siberia (between 1950 and 1960) belong to the Arctic-2 and Arctic-3 lineages and share 98 center dot 6-99 center dot 2% N gene identity with contemporary viruses. Two lineages of Arctic-like Viruses were identified in Southern Asia and the Middle East (Arctic-like-1) and eastern Asia (Arctic-like-2). A time-scaled tree demonstrates that the time of the most recent common ancestor (TMRCA) of Arctic and Arctic-like viruses is dated between 1255 and 1786. Evolution of the Arctic viruses has occurred through a northerly spread. The Arctic-like-2 lineage diverged first, whereas Arctic Viruses share a TMRCA with Arctic-like-1 viruses.