Prospective 12-Month Study of Intrathecal Baclofen Therapy for Poststroke Spastic Upper and Lower Extremity Motor Control and Functional Improvement
Prospective 12-Month Study of Intrathecal Baclofen Therapy for Poststroke Spastic Upper and Lower Extremity Motor Control and Functional Improvement
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DOI：
10.1111/j.1525-1403.2010.00308.x
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发表时间：
2011-01-01
期刊：
影响因子：
2.8
通讯作者：
Simpson, Richard K.
中科院分区：
文献类型：
--
作者：
Schiess, Mya C.;Oh, Irene J.;Simpson, Richard K.
目的：评估鞘内注射巴氯芬（ITB）治疗卒中后痉挛性轻偏瘫对生活质量、功能独立性和上下肢（UE、LE）运动功能的影响。材料和方法：对至少6个月卒中相关痉挛性轻偏瘫的成年男性和女性进行前瞻性观察研究，改良Ashworth量表（MAS）评定UE和LE评分>= 2。患者作为自己的对照组，植入前与ITB后12个月的测量结果进行比较，包括：MAS、手动肌肉测试（MMT）、步态距离/速度、功能独立性测量（ADL）、卒中特异性生活质量量表（SSQL）和上肢手动活动日志。12个月ITB治疗后，26例患者（卒中后= 6.4垂直于9年）显示：1）大多数LE肌群的MAS降低/MMT增加（p
Objectives: To assess the effects of intrathecal baclofen (ITB) therapy for the treatment of poststroke spastic hemiparesis on quality of life, functional independence, and upper, lower extremity (UE, LE) motor functions.Materials and Methods: Prospective observational study of adult men and women with a minimum 6-month stroke-related spastic hemiparesis graded as >= 2 in UE and LE on Modified Ashworth Scale (MAS). Patients served as their own controls with measures compared pre-implant with 12 months post ITB including: MAS, manual muscle test (MMT), gait distance/velocity, Functional Independence Measures (FIM), stroke-specific quality of life scale (SSQL), and upper extremity manual activity log.Results: After 12-month ITB therapy, 26 patients (poststroke = 6.4 perpendicular to 9 years) demonstrated 1) reduced MAS/increased MMT for most LE muscle groups (p