Effect of suplatast tosilate, an antiallergic selective Th2 cytokine inhibitor, on acute eosinophilic myocarditis: a case report
Effect of suplatast tosilate, an antiallergic selective Th2 cytokine inhibitor, on acute eosinophilic myocarditis: a case report
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DOI：
10.1007/s10380-002-0689-2
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发表时间：
2003-05
影响因子：
1.5
通讯作者：
S. Umemoto;Kazuo Itagaki;M. Kimura;S. Itoh;Masakazu Tanaka;M. Haraguchi;M. Matsuzaki
中科院分区：
文献类型：
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作者：
S. Umemoto;Kazuo Itagaki;M. Kimura;S. Itoh;Masakazu Tanaka;M. Haraguchi;M. Matsuzaki
我们遇到了一个44岁的急性嗜酸性心肌炎妇女，在嗜酸性粒细胞明显浸润到心肌的区域显示白细胞介素-4免疫染色阳性。当单用强的松龙治疗无效时，辅以抗过敏选择性Th2细胞因子抑制剂tosilate suplatast治疗，可改善患者的炎症，降低心脏酶水平，并可减少皮质类固醇剂量而无任何不良反应。
We encountered a 44-year-old woman with acute eosinophilic myocarditis that showed positive immunostaining for interleukin-4 in the area of marked infiltration of eosinophils into the myocardium. When prednisolone alone proved ineffective, supplementary treatment with suplatast tosilate, an antiallergic selective Th2 cytokine inhibitor, improved the patient's inflammation, reduced the level of cardiac enzymes, and allowed for a reduction in corticosteroid dosage without any adverse effects.