PSYCHOSTIMULANT SELF-ADMINISTRATION BY BEAGLE DOGS IN A PROGRESSIVE-RATIO PARADIGM
PSYCHOSTIMULANT SELF-ADMINISTRATION BY BEAGLE DOGS IN A PROGRESSIVE-RATIO PARADIGM
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DOI：
10.1007/bf00433496
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发表时间：
1981-01-01
影响因子：
3.4
通讯作者：
SILCOX, DL
中科院分区：
文献类型：
--
作者：
RISNER, ME;SILCOX, DL
可卡因，安非他明，马吲哚和芬氟拉明的相对增强效果进行了量化使用的累进比率范例。在每天三次1小时的试验期间，六只插管的比格犬获得响应-视情况而定的药物输注。根据预定的时间表，每天增加每次试验获得1次输注的应答要求，直到犬未能完成必要的固定比例（FR），即，直到它们的比率行为达到一个临界点。芬氟拉明（剂量范围为每次输注0.0625-4.0 mg/kg）不能维持最低要求（FR 30）或以上的自我给药行为。相比之下，所有剂量的可卡因（0.2-1.6 mg/kg/输注）、d-苯丙胺（0.035-0.28 mg/kg/输注）和马吲哚（0.0225-0.18 mg/kg/输注）在大FR值下持续应答。最高的FR值由可卡因维持，其次是d-苯丙胺，然后是马吲哚。一般而言，犬完成较高FR的药物剂量较高。
The relative reinforcing efficacy of cocaine, amphetamine, mazindol and fenfluramine was quantified using a progressive-ratio paradigm. Six catheterized beagle dogs were given access to response-contingent drug infusions during three 1 h trials each day. According to a predetermined schedule, the response requirement to obtain 1 infusion each trial was increased daily until the dogs failed to complete the necessary fixed-ratio (FR), i.e., until they reached a break-point in their ratio behavior. Fenfluramine (in doses ranging from 0.0625-4.0 mg/kg per infusion) did not maintain self-administrative behavior at or above the minimum requirement (FR 30). In contrast, all doses of cocaine (0.2-1.6 mg/kg per infusion), d-amphetamine (0.035-0.28 mg/kg per infusion), and mazindol (0.0225-0.18 mg/kg per infusion) sustained responding at large FR values. The highest FR values were maintained by cocaine, followed by d-amphetamine, then mazindol. Generally the dogs completed higher FR for higher doses of a drug.