Dissociable age and memory relationships with hippocampal subfield volumes in vivo: Data from the Irish Longitudinal Study on Ageing (TILDA)
Dissociable age and memory relationships with hippocampal subfield volumes in vivo: Data from the Irish Longitudinal Study on Ageing (TILDA)
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DOI：
10.1038/s41598-019-46481-5
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发表时间：
2019-07-29
影响因子：
4.6
通讯作者：
Meaney, James
中科院分区：
文献类型：
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作者：
Carey, Daniel;Nolan, Hugh;Meaney, James
在动物模型中广泛显示了海马子区域在记忆功能中的异质性特化。然而，很少有在人体内的研究探讨海马子区解剖和记忆性能之间的对应关系在老龄化。在这里，我们使用了一个经过充分验证的自动MR分割协议，以测量海马子场体积在436个非痴呆的成年人年龄在50岁以上。我们探讨了海马子域体积和言语情景记忆之间的关系，索引的词表回忆在立即介绍和以下延迟。在单独的多层次模型中，每个任务，我们测试的线性和非线性之间的关联回忆性能和子域量。完全调整的模型显示，即时和延迟的回忆都与三次拟合的体积子域CA 1，CA 2/3，CA 4，分子层，颗粒细胞层的齿状回;此外，这些影响是部分分离的二次年龄趋势，观察下托，分子层，海马尾，和CA 1。此外，语义流畅性数据的分析显示，几乎没有证据表明与海马子区体积的强大关联。我们的研究结果表明，特定的海马子字段与非痴呆老年人的记忆编码和检索性能表现的关联;这些影响部分与年龄相关的萎缩和检索巩固的语义类别无关。
The heterogeneous specialisation of hippocampal subfields across memory functions has been widely shown in animal models. Yet, few in vivo studies in humans have explored correspondence between hippocampal subfield anatomy and memory performance in ageing. Here, we used a well-validated automated MR segmentation protocol to measure hippocampal subfield volumes in 436 non-demented adults aged 50+. We explored relationships between hippocampal subfield volume and verbal episodic memory, as indexed by word list recall at immediate presentation and following delay. In separate multilevel models for each task, we tested linearity and non-linearity of associations between recall performance and subfield volume. Fully-adjusted models revealed that immediate and delayed recall were both associated with cubic fits with respect to volume of subfields CA1, CA2/3, CA4, molecular layer, and granule cell layer of dentate gyrus; moreover, these effects were partly dissociable from quadratic age trends, observed for subiculum, molecular layer, hippocampal tail, and CA1. Furthermore, analyses of semantic fluency data revealed little evidence of robust associations with hippocampal subfield volumes. Our results show that specific hippocampal subfields manifest associations with memory encoding and retrieval performance in non-demented older adults; these effects are partly dissociable from age-related atrophy, and from retrieval of well-consolidated semantic categories.