Maternal generalized anxiety disorder during pregnancy and fetal brain development: A comparative study on cord blood brain-derived neurotrophic factor levels
Maternal generalized anxiety disorder during pregnancy and fetal brain development: A comparative study on cord blood brain-derived neurotrophic factor levels
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DOI：
10.1016/j.jpsychores.2013.04.010
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发表时间：
2013-10-01
影响因子：
4.7
通讯作者：
Tasyurek, Erkan
中科院分区：
文献类型：
--
作者：
Uguz, Faruk;Sonmez, Erdem Onder;Tasyurek, Erkan
目的：本研究旨在探讨是否母亲GAD在怀孕期间影响胎儿循环脑源性神经营养因子（BDNF），这在神经元发育中起着重要作用，通过比较脐血BDNF水平在新生儿的妇女和没有GAD.Methods：研究样本包括19名妇女GAD和25名妇女没有任何精神疾病。广泛性焦虑症和其他精神疾病的诊断是通过结构化临床访谈的精神疾病的诊断和统计手册，第四版。结果：健康孕妇新生儿脐血BDNF水平约为GAD孕妇新生儿的2倍，差异有统计学意义。GAD在怀孕期间的持续时间是唯一的变量与脐带血BDNF levels.Conclusions：研究结果表明，在怀孕期间延长产妇GAD可能会产生负面影响胎儿的神经发育，通过较低水平的循环BDNF。(C)2013 Elsevier Inc. All rights reserved.
Objectives: The study aimed to investigate whether maternal GAD during pregnancy affects fetal circulating brain-derived neurotrophic factor (BDNF), which plays important roles in neuronal development, by comparing cord blood BDNF levels in newborn infants of women with and without GAD.Methods: Study sample included 19 women with GAD and 25 women without any psychiatric disorder. GAD and other psychiatric diagnoses were screened by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The blood sample for the determination of BDNF level was obtained from the umbilical cord during delivery.Results: Cord blood BDNF levels in newborn infants of healthy women were approximately two-fold compared to newborn infants of women with GAD, and the difference was statistically significant. The duration of GAD during pregnancy was the only variable correlating with cord blood BDNF levels.Conclusions: The study results imply that prolonged maternal GAD during pregnancy may negatively influence neurodevelopment of the fetus through lower levels of circulating BDNF. (C) 2013 Elsevier Inc. All rights reserved.