Cerebral blood flow increases over the first three days of life in extremely preterm neonates
Cerebral blood flow increases over the first three days of life in extremely preterm neonates
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DOI：
10.1136/fn.78.1.f33
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发表时间：
1998-01-01
影响因子：
4.4
通讯作者：
Wyatt, JS
中科院分区：
文献类型：
--
作者：
Meek, FH;Tyszczuk, L;Wyatt, JS
Aim-To measure changes in cerebral haemodynamics over the first three days of life in very preterm infants with normal brains. Methods-11例机械通气婴儿（中位胎龄26周），无证据显示颅内超声检查有重大异常，进行了研究。脑血流量（CBF）和脑血容量（CBV）在出生后的前三天内至少测量两次。（p=0.02;逐步线性回归），这与平均动脉血压，PaCO 2，和红细胞压积。结论-这种变化很可能是代表一个正常的适应性反应的脑循环出生后的生活。
Aim-To measure changes in cerebral haemodynamics over the first three days of life in very preterm infants with normal brains.Methods-Eleven mechanically ventilated infants (median gestational age 26 weeks) without evidence of major abnormalities on cranial ultrasound examination were studied. Cerebral blood flow (CBF) and cerebral blood volume (CBV) were measured using near infrared spectroscopy at least twice over the first three days of life.Results-Cerebral blood flow increased significantly with time (p=0.02; stepwise linear regression) and this was independent of mean arterial blood pressure, PaCO2, and haematocrit.Conclusion-This change is likely to represent a normal adaptive response of the cerebral circulation to postnatal life.