Abnormal N-glycosylation of the immunoglobulin G κ chain in a multiple myeloma patient with crystalglobulinemia:: Case report
Abnormal N-glycosylation of the immunoglobulin G κ chain in a multiple myeloma patient with crystalglobulinemia:: Case report
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DOI：
10.1532/ijh97.06074
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发表时间：
2007-04-01
影响因子：
2.1
通讯作者：
Mori, Mayumi
中科院分区：
文献类型：
--
作者：
Hashimoto, Ryo;Toda, Tosifusa;Mori, Mayumi
单克隆免疫球蛋白（晶体球蛋白）的自发结晶是多发性骨髓瘤的一种罕见并发症。我们描述了一个64岁的日本男性皮肤溃疡和肾功能衰竭与免疫球蛋白G κ多发性骨髓瘤。在室温下他的血清中检测到了结晶免疫球蛋白。通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳和质谱分析患者的晶体球蛋白，表明结晶是由于免疫球蛋白轻链的异常糖基化。用沙利度胺和地塞米松治疗改善了患者四肢严重的皮肤溃疡，部分逆转了他的肾功能衰竭。这是第一份可能由轻链N-聚糖修饰引起的免疫球蛋白异常糖基化的报告。我们得出的结论是，免疫球蛋白轻链的异常糖基化可能是患者皮肤溃疡和肾功能障碍的原因。
Spontaneous crystallization of monoclonal immunoglobulins (crystalglobulin) is a rare complication of multiple myeloma. We describe a 64-year-old Japanese man with skin ulcers and renal failure associated with immunoglobulin G kappa multiple myeloma. Crystallized immunoglobulin was detected in his serum at room temperature. Analysis of the patient's crystalglobulin by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and mass spectrometry suggested that the crystallization was due to abnormal glycosylation of the immunoglobulin light chain. Treatment with thalidomide and dexamethasone improved the severe skin ulcers on the patient's extremities and partially reversed his renal failure.This report is the first of abnormal glycosylation of immunoglobulin possibly caused by modification of N-glycans in the light chain. We concluded that abnormal glycosylation of the immunoglobulin light chain might be the cause of the patient's skin ulcers and renal dysfunction.