Risk Factors for Soft Tissue Sarcomas in Childhood: A Case-Control Study
Risk Factors for Soft Tissue Sarcomas in Childhood: A Case-Control Study
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儿童期软组织肉瘤的危险因素：病例对照研究
DOI：
10.1177/030089168907500418
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发表时间：
1989
期刊：
影响因子：
1.9
通讯作者：
B. Terracini
中科院分区：
文献类型：
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作者：
C. Magnani;G. Pastore;L. Luzzatto;M. Carli;P. Lubrano;B. Terracini
1983-84年在都灵和帕多瓦（意大利）进行了一项以医院为基础的软组织肉瘤病例对照研究。36例横纹肌肉瘤患儿（RMS）和16例非RMS- sts患儿)与326例对照进行比较。通过对在医院照顾儿童的亲属的访谈，收集了父母吸烟习惯和职业、父母和儿童接触电离辐射的历史、儿童疾病和其他一些变量。分娩时母亲年龄在30岁以上（STS: OR = 1.5， C.I. = 0.8-2.9; RMS: OR = 1.9， C.I. = 0.9-4.0）和“子宫内”接受诊断性辐射（STS: OR = 1.9， C.I. = 0.5-6.5，基于4例）存在无统计学意义的关联。与儿童以前的疾病没有关联。在RMS和STS病例和对照组中，父亲和母亲的吸烟习惯相似。一些积极的联系，无论是母亲或父亲的职业史被确定。由于大量的比较和小的绝对数字，它们很难解释。其中包括从事医生和护士、农民、纺织工人和机床操作员等职业的产妇。还观察到父亲的职业如屠夫、建筑工人或生产家用电器的工作与此有关。一个病例和没有对照组报告了一个患乳腺癌的姨妈。
A hospital-based case-control study on soft tissue sarcomas (STS) was conducted in 1983-84 in Torino and in Padova (Italy). Cases (36 children with rhabdomyosarcoma (RMS) and 16 non RMS-STS) were compared to 326 controls. Histories of parental smoking habits and occupations, parental and children's exposure to ionizing radiation, children's diseases and some other variables were collected through interviews to the relatives attending the child in the hospital. A non statistically significant association was observed with both maternal age above 30 at child's birth (STS: OR = 1.5, C.I. = 0.8-2.9; RMS: OR = 1.9, C.I. = 0.9-4.0) and « in utero » exposure to diagnostic radiation (STS: OR = 1.9, C.I. = 0.5-6.5, based on 4 cases). No association was found with children's previous diseases. Paternal and maternal smoking habits were similar for RMS and STS cases and controls. Some positive associations with either maternal or paternal occupational histories were identified. They are difficult to interpret in view of the large number of comparisons and small absolute figures. They included maternal employment as medical doctor and nurse, farmer, textile worker and machine tool operator. An association was also observed with paternal occupation as butcher, building worker or employment in the production of domestic appliances. One case and no controls reported a maternal aunt affected by breast cancer.
DOI：
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发表时间：
1982
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Grufferman,S;Wang,HH;DeLong,ER;Kimm,SY;Delzell,ES;Falletta,JM
通讯作者：
Falletta,JM