How does endothelial cell injury start? The role of endothelin in systemic sclerosis.
How does endothelial cell injury start? The role of endothelin in systemic sclerosis.
复制标题
内皮细胞损伤如何开始？内皮素在系统性硬化症中的作用。
DOI：
10.1186/ar2186
复制
发表时间：
2007
影响因子：
4.9
通讯作者：
Distler, Oliver
中科院分区：
文献类型：
--
作者：
Abraham, David;Distler, Oliver
大量的研究时间已经投入到旨在阐明系统性硬化症（SSc）的致病过程的研究中。尽管如此，生物医学科学的主要挑战仍然存在，例如确定决定SSc易感性的关键因素，以及阐明引起内皮细胞损伤并最终引起导致病理性血管变化的生物级联反应的起始事件的确切性质。所涉及的因素可能包括遗传干扰、环境因素、组织损伤、感染和缺氧/氧化应激。与确定起始事件同样重要的是识别和表征在驱动血管疾病进展中具有重要功能的关键因素，因为这些因素是治疗干预的潜在靶点。本文综述了内皮素作为多效性介质的作用，对SSc发病机制的各个方面，如炎症，血管病变和组织重塑的影响。
A considerable amount of research time has been invested in studies aimed at elucidating pathogenic processes in systemic sclerosis (SSc). Despite this, major challenges for biomedical science remain, such as identification of the key factors that determine susceptibility to SSc, and elucidation of the precise nature of the initiating event that causes endothelial cell injury and ultimately brings about the biological cascade(s) that lead to the pathologic vascular changes. Involved factors are likely to include genetic perturbations, environmental cues, tissue injury, infection and hypoxia/oxidative stress. As important as determining the initiating events are the identification and characterization of key factors that are functionally important in driving vascular disease progression, because these factors are potential targets for therapeutic intervention. This article reviews the role of endothelin as an example of a pleiotropic mediator with effects on various aspects of SSc pathogenesis, such as inflammation, vasculopathy and tissue remodelling.